Therapeutics - Chemo 2

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Author:
kyleannkelsey
ID:
300687
Filename:
Therapeutics - Chemo 2
Updated:
2015-04-13 14:51:26
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Therapeutics Chemo
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Therapeutics - Chemo
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  1. What are the Common uses for Eribulin?
    Metastatic breast cancer previously treated w/ anthracycline
  2. What are the SE for Eribulin?
    • Neutropenia
    • PN (DLT)
    • QT prolongation
  3. What special information should you know about Eribulin?
    • No premeds
    • CAN use w/ PVC
  4. What are the Common uses for Vincristine?
    ALL, Hodgkin’s lymphoma, NHL, multiple myeloma, testicular cancer
  5. What are the SE for Vincristine?
    • PN (DLT, HT)
    • Constipation (give a scheduled stool softener)
  6. What special information should you know about Vincristine?
    • Vesicant
    • NMT 2 mg dose to avoid PN
    • NO IT ADMIN
  7. What drugs should you not give intraathecally?
    Vinca alkaloids
  8. What are the Common uses for Vinorelbine?
    Breast, NSCLC, ovarian, head and neck
  9. What are the SE for Vinorelbine?
    • Neutropenia
    • PN
  10. What special information should you know about Vinorelbine?
    • Vesicant
    • NO IT ADMIN
  11. What are the Common uses for Vinblastine?
    Bladder, Hodgkin’s lymphoma, NHL, testicular, NSCLC
  12. What are the SE for Vinblastine?
    • Myelosuppression (DLT)
    • Muscle aching
  13. What special information should you know about Vinblastine?
    • Vesicant
    • NO IT ADMIN
  14. What are the Common uses for Vincristine sulfate liposome?
    Philadelphia negative ALL
  15. What are the SE for Vincristine sulfate liposome?
    • PN
    • Constipation
    • Pneumonia
  16. What special information should you know about Vincristine sulfate liposome?
    Comes in 3 separate vials (sodium phosphate, sphingomyelin/cholesterol liposome and vincristine) and must be mixed in a water bath at 145-153 ̊ F
  17. What are the Topoisomerase I inhibitors?
    -tecan
  18. What are the Topoisomerase II inhibitors?
    • -rubicin
    • -poside
    • Mitoxantrone
  19. What are the Common uses for Irinotecan?
    SCLC, NSCLC, colorectal, breast
  20. What are the SE for Irinotecan?
    • Acute diarrhea: cholinergic process; self-limiting, Atropine 0.25 – 1 mg IV
    • Delayed diarrhea (DLT, HT): life-threatening, > 12 hr after dose
  21. What special information should you know about Irinotecan?
    • Loperamide 4 mg at onset and 2 mg q2h until resolution of diarrhea for 12 hrs
    • Diarrhea worsens or doesn’t improve = come in and get it checked out
  22. What are the Common uses for Etoposide?
    SCLC, NSCLC, testicular, NHL, gastric cancer
  23. What are the SE for Etoposide?
    Orthostatic hypotension or Hypotension during admin
  24. What special information should you know about Etoposide?
    Stability is concentration dependent – more conc. = less stable

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