Therapeutics - Chemo 3

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Author:
kyleannkelsey
ID:
300689
Filename:
Therapeutics - Chemo 3
Updated:
2015-04-13 14:52:32
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Therapeutics Chemo
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Therapeutics - Chemo
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Therapeutics - Chemo
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  1. What are the Common uses for Teniposide?
    NHL, SCLC, bladder
  2. What are the SE for Teniposide?
    Hypotension – rate dependent
  3. What special information should you know about Teniposide?
    No PVC-containing products
  4. What drug can be used as an antidote to extravasation by anthracyclines?
    Totect
  5. What are the class effects fo anthracycline derivatives?
    • Radiation recall
    • Vesicants (treat with Totect)
    • Red Urine
    • Delayed Cardiotoxicity (DLT, HT)
  6. What are the Anthracyclines?
    -rubicin
  7. What are the Common uses for Doxorubicin?
    Breast, NHL, bladder, sarcoma, MM
  8. What are the SE for Doxorubicin?
    Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
  9. What special information should you know about Doxorubicin?
    • Baseline ejection fraction before treatment – cannot be low, must be > 40
    • Max dose of 550 mg/m2
  10. What are the Common uses for Daunorubicin?
    AML and ALL
  11. What are the SE for Daunorubicin?
    Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
  12. What special information should you know about Daunorubicin?
    • Baseline ejection fraction before treatment – cannot be low, must be > 40
    • Max dose of 550 mg/m2
  13. What are the Common uses for Idarubicin?
    AML and ALL
  14. What are the SE for Idarubicin?
    Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
  15. What special information should you know about Idarubicin?
    • Baseline ejection fraction before treatment – cannot be low, must be > 40
    • Max dose of 150 mg/m2
  16. What are the Common uses for Epirubicin?
    Breast, SCLC, NSCLC, NHL, bladder, ovarian
  17. What are the SE for Epirubicin?
    Cardiotoxicity (DLT, HT) – delayed (acute is not really an issues, as it is usually self-resolving)
  18. What special information should you know about Epirubicin?
    • Baseline ejection fraction before treatment – cannot be low, must be > 40
    • Max dose of 900 mg/m2
  19. What are the Common uses for Mitoxantrone?
    Prostate cancer, MM
  20. What are the SE for Mitoxantrone?
    Cardiotoxicity (DLT, HT), blue green discoloration of urine, skin, sclera
  21. What are the SE for Busulfan?
    • Pulmonary fibrosis “Busulfan lung” (Short survival after diagnosis)
    • Usually occurs after 3-4 years of treatment
    • Presentation: Non-productive cough, Shortness of breath, weight loss, Abnormal chest x-ray
  22. What special information should you know about Mitoxantrone?
    • Baseline ejection fraction before treatment
    • Do not exceed 140 mg/m2
  23. What special information should you know about Busulfan?
    • Readily crosses blood brain barrier
    • CNS levels = plasma levels
    • Stem cell transplant/bone marrow transplant
    • Seizures –Prophylax with phenytoin (Keppra also used) for 48-72 hrs after dose completed
    • IV and PO = not interchangeable

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