Mediate cytotoxic responses directed against intracellular pathogens.
Mediate antibody production against extracellular pathogens and bacterial toxins.
Mediate anti-microbial immunity at epithelial/mucosal surfaces.
Cytotoxic innate immune cell that can kills pathogens without prior immune exposure and do no require MHC.
Major effectors in anaphylactic reactions, hypersensitivity disease, and metazoan parasite infections.
Eosinophils secrete ___________ that suppress _____________.
prostaglandins; mast cell degranulation
Granules of eosinophils are rich in... (3)
major basic protein, histiminase, and peroxidase/phospholipase that antagonize mast cell products
Mast cells are found in ______________; they play a direct role in regulation of _____________; they play an indirect role in control of ___________; they also produce _______ to stimulate a Th2 response.
connective tissues; regional blood flow; secretions from intestine and pulmonary tract; IL-4
Endothelia express _________ in response to pro-inflammatory cytokines.
The endothelial basement membrane provides a hold for _____________ and a substrate for launching the ______________.