A special type of thyroid dysfunction that results in inadequate T3/T4 synthesis and bilateral enlargement of the thyroid glands
What causes Goitre?
Iodine deficiency, iodine toxicity or goitrogenic plants
Why is there bilateral enlargement of the thyroid glands during goitre?
TSH production leads to thyroid enlargement but as there is no available iodine there is decreased T4 and T3 production. This feeds back to the pituitary and leads to increased TSH production, and the cycle continues.
What family of plants is goitrogen found in?
Brassica eg kale, rape
Give an example of when excess iodine is fed in the diet
Seaweed fed to mares
Is hyperthyroidism common in cats or dogs?
What is the most common cause of hyperthyroidism?
Parathyroid hypo function is rare but when might this occur?
When the thyroid is surgically removed
What are the three causes of secondary hyperparathyroidism?
Renal - decreased GFR, increased phosphate retention and relative hypocalcaemia, continued stimulation of the parathyroid gland
Nutritional - diet high in phosphate/low in calcium/low in vitamin D
Psuedohyperparathyroidism - tumours of non endocrine origin secreted PTHrP
What can cause primary hyperparathyroidism?
What are the four causes of pancreatic islet hypo function?
Vacuolar degeneration, amyloidosis, immune mediated destruction, secondary to pancreatitis
What clinical syndrome is caused by pancreatic islet hypo function?
What causes pancreatic islet hyper function?
Non functional neoplasms and hyperplasia less common
What type of tumour is more common: a cell or b cell pancreatic tumours? And what hormone do they secrete?