What is the Wnt pathway in liver?
pathway that causes an accumulation of beta-catenin in teh cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of TFs
Without Wnt signaling, the Beta-catenin won't accumulate since a destruction complex would normally degrade it, which includes APC, and others. Beta-catenin is ubiquitlyated and sent to a proteasome.
However, when Wnt binds Frazzled, the destruction complex function becomes disrupted. This is due to Wnt causing the translocation of the negative Wnt regulator, Axin, and the destruciton complex to teh membrane.