Lecture 18 Acquired Immunity

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Author:
leti563
ID:
301429
Filename:
Lecture 18 Acquired Immunity
Updated:
2015-04-24 02:57:40
Tags:
Acquired Immunity Specific
Folders:
Acquired Immunity,Specific Immunity
Description:
Lecture 18 Acquires/ Specific Immunity
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  1. Active Immunity
    • *Exposure to viruses
    • *Vaccines (dead, alive, partially dead)
    • *Fast response
    • *Always present after initial exposure/ MEMORY
  2. Passive Immunity/ Short term
    • *fetus
    • *No memory
    • * Transferred from mom for short term only.
  3. Lymphocytes
    RESPONSIBLE for acquired immunity.

    B, T

    Programmed to detect self from non self cells
  4. Clonal Expansion Process
    1) Naive lymphocyte is exposed to pathogen

    2) Cells begin to clone themselves.

    3) Effector cells and Memory cells are created. 

    Effector cells aid in that response, Memory cells are stored for future exposure.
  5. B Lymphocytes
    • *Antibody production
    • * In Bone Marrow

    * Respond to specific antigen
  6. Antibodies Regions
    Y= two arms on top ---> Fab = Recognition

      = Lower part (stick) --> Fc= Class of Ab
  7. IgG

    Antibodies
    • * 75%
    • * 2ary response
    •    -Activate complement (Inc inflammation/ Histamie MAC)

    *MEMORY CELLS ALWAYS RELEASE IgG
  8. IgA

    Antibodies
    External Secretions

    • *Tears
    • *Mucus
    • *Breast Milk
  9. IgE  

    Antibodies
    Gut Parasites
  10. IgM 

    Antibodies
    Primary response
  11. IgD 

    Antibodies
    On surface of B Lymphocytes

    Purpose is unknown
  12. T Lymphocytes
    *Viruses inside cells/ Encapsulated Bacteria

    *Thymus sorts bacteria

    • 2 types are
    • *Cytotoxic and Helper
  13. MHC1
    On surface of EVERY nucleated cell

    Interacts with Cytotoxic T Cells

    • *Checks every cell/ Monitors Cells
    • *Determines whether cells live or die
  14. MHC 2
    • Present of surfce of APC ONLY!!!!!!
    • (Macrophages, Dentritic, B cells)

    Interact with T Cells

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