Pharm- Drugs

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Author:
Mawad
ID:
301629
Filename:
Pharm- Drugs
Updated:
2015-04-27 14:29:45
Tags:
vetmed drugs pharm
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Description:
vetmed, drugs for pharm final
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  1. Isoproterenol (heart)
    sympathomimetic; produces bronchodilation by relaxing smooth mm. through beta-2 stimulation; increases HR by cardiac beta-1 stimulation
  2. Phenylephrine (heart)
    sympathomimetic; acts on alpha receptors to contract vascular smooth mm. and increase BP
  3. Phentolamine (heart, eye)
    alpha-1 antagonist to cause vasodilation of vascular smooth mm. and decrease BP; miosis- radial antagonist
  4. Propranolol (heart)
    non-selective beta blocker; competitive antagonist; causes decreased cardiac output (decreases HR)
  5. Physostigmine (eye)
    indirect agonist; anticholinesterase blocker; prolongs the effects of Ach; miosis
  6. Amphetamine (eye)
    indirect-acting radial agonist; increases release of dopamine, NE, serotonin; inhibits re-uptake of dopamine and NE pre-synaptically; mydriasis
  7. Cocaine (eye)
    indirect radial agonist; blocks pre-synaptic re-uptake of dopamine, NE, and serotonin, prolonging their effects; potentiates actions of released NE; mydriasis
  8. Morphine (eye)
    enhances activity in oculomotor nucleus of brain; miosis when given systemically
  9. Atropine (heart, eye)
    anti-muscarinic; surmountable/competitive antagonist of Ach; increases HR by blocking vagal activity (which usually causes SA node to decrease pacemaker firing); sphincter antagonist --> mydriasis
  10. Epinephrine (heart)
    direct agonist of alpha and beta receptor (more-so beta);vasodilation to skeletal mm. by beta-2 receptor stimulation; vasoconstriction to viscera and skin by alpha-1 receptor stimulation; relax smooth muscles of bronchi; increases HR
  11. Norepinephrine (heart, eye)
    direct agonist of adrenergic receptors; peripheral vasoconstriction by alpha-1 stimulation; increased HR by beta-1 stimulation; radial agonist --> mydriasis
  12. Acetylcholine (heart, eye)
    direct agonist of muscarinic receptors; muscarinic receptors in heart linked to K+ channels by G-protein --> increased pacemaker firing and increased HR; sphincter agonist --> miosis
  13. [Optional] Xylazine
    alpha-2 agonist; pre-synaptic negative feedback of NE release by mimicking NE; low specificity; analgesic-sedative
  14. [Optional] Yohimbine
    alpha-2 (and alpha-1 and other receptors at higher doses) antagonist; low specificity; mydriasis; vasodilator; reverses xylazine
  15. [Optional] Acepromazine
    blocks dopaminergic receptors in the CNS, causing neuroleptic and anti-emetic effects; blocks alpha-adrenergic receptors, lowering BP by blocking NE; low specificity

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