CHP.15 - HALLUCINOGENS

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dsalanga11292
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301643
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CHP.15 - HALLUCINOGENS
Updated:
2015-04-27 19:18:07
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lsd mdma salvia pcp ketamine gamma
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cards for chp. 15 - hallucinogens
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  1. LSD is derived from
    the ergot fungus
  2. a) Hallucinogens have similar structure to ______ ; Indoleamine like drugs have similar structures to _______
    b) bufotanin is 
    c) harming is
    • a) monoamines; seratonin
    • b) natural toxin in plants and animals
    • c) plant derived drug
  3. Mescaline is a ________ like drug which effects _____ and _______
    catecolomene; noepineprhine; dopamine
  4. LSD - 
    full effect dose = _____ mg
    average dose = _____ mg

    ___% enters the brain

    half life = ___ - ___ hrs
    effects starting in __ - __ mins after intake
    • full effect = 200 micro gram
    • average = 200-300 microgram

    1% enters the brain

    • half life = 2 1/2 - 5 hrs
    • effects starting in 30 - 90 mins after intake
  5. LSD NEUROPHYSIOLOGY

    LSD has ____ effects on the brain
    LSD in the PNS is a ________
    unknown; seratonin reuptake inhibitor
  6. LSD NEUROPHYSIOLOGY

    LSD in the CNS blocks _______ causing _______
    LSD effects 3 brain regions: alpha nuclei, locus coeruleus, cortex
    5ht-2a (agonist); cascade
  7. LSD effects on the alpha nuclei - __ agonist, leads to ____ of locus coeruleus, causes ___ ___ effect
    1a; suppression; enhanced novelty
  8. LSD effects on the cortex - changes in ______, causing ______ effects and ______
    glutomate; excitatory effects; meta thoughts
  9. LSD Hallucinations stages: 

    1st stage - 

    2nd stage -

    Hallucination theory -
    1st stage: geometrically based patterns, spirals, spider webs

    2nd stage: meaningful images of ppl, animals places, religious imagery

    Hallucination Theory - too much sensory input
  10. Subjective effects of LSD:
    feeling emotional, worldly and connected, spiritual, pleasure in art, synesthesia (confusion of senses), repressed thoughts, unrecognized feelings, false reports of increased keenness
  11. LSD Tolerance:
    can develop in ____ but dissipates in _____
    Addictive? Reinforcing Qualities?

    Cross tolerance to ___ and ___ but not ___ or ____
    2-3 days; a week; not addictive, no reinforcing qualities

    Cross tolerance: DMT and Mescaline; not amphetamines or THC
  12. LSD Withdraw - Flashbacks
    residual effects that are unpredictable, usually perceptual distortions
  13. Chemical name of Ecstasy
    3,4 Methylene-Dioxy-Meth-Amphetamine
  14. MDMA - 
    average dose = ____ mg
    peak blood lvls in ___ 
    half life = _____

    metabolized into ___ or _____ ______
    • average dose = 100 mg
    • peak blood lvls in 2 hrs
    • half life = 8 hrs

    metabolized: MDA; excreted unchanged
  15. MDMA NEUROPHYSIOLOGY

    release and blocks reuptake of  of ____, _____, and ____, and the hormone _____
    seratonin, norepinephrine, dopamine; oxytocin
  16. SALVIA - 
     
    average dose = ____ mg
    duration of high = __- __ mins
    has a ____ toxicity and is a ______ hallucinogen
    • average dose = 200 micrograms
    • duration of high = 5 - 30 mins

    low; naturally occuring
  17. SALVIA NEUROPHYS.

    effects the ______ (brain region) causing ______

    highly selective _____ agonist, partial ____ agonist, no action on ____
    cerebellum; loss of motor coordination

    opioid receptor; d2; seratonin
  18. PCP and Ketamine are _________
    dissociative drugs
  19. PCP was used as a ______ since it didn't ______

    Has a reputation for ______ while high
    anesthetic; depress bp, hr or respiration

    mutilation
  20. PCP - emergent delirium
    disorientation, deliriums, and agitation when coming out of anesthetic state
  21. PCP effects felt within ____ if inhaled or injected, ______ if taken orally

    effects lasts btwn ___ - ___ __
    minutes; 20-40 mins

    30-45 mins
  22. PCP and KETAMINE NEUROPHYS.

    block ___ receptors (_____) antagonists, which causes ____ and ____

    alters the chemicals _____, _____, _____, ____

    Generalization to other drugs?
    ndma receptors (glutomate); blocked learning, no memories

    norepinephrine, seratonin, acetocholine, dopamine

    no generalization to other drugs
  23. GHB is a _____ in the body as a _____ of _____
    naturally occuring; metabolite; GABA
  24. GHB NEUROPHYS. - 

    ____ ____, binds to ___ receptor and ____ receptors at the synapse

    Effects on dopamine -

    Partially generalizes to ___, ___, and ____ but not _____
    active reuptake, ghbr, gaba

    dopamine - prevented release, then rush

    morphine, benzos, ethanol; barbiturates
  25. GHB Effects - similar to _____
    alcohol
  26. DEXTREOMETHORPHAN NEUROPHYS. -

    _____ as an ndma receptor _____

    activation of _____ receptor to reduce _____

    converted quickly in the active ____ (_____) which is more potent
    low affinity; antagoinst

    sigma1; coughing

    metabolite (dextrophan)
  27. Effects of DXM and MEPHEDROME at high doses:
    ataxia, dizziness, euphoria, visual hallucinations, altered time perception

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