CHP. 14 - CANNABIS

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Author:
dsalanga11292
ID:
301646
Filename:
CHP. 14 - CANNABIS
Updated:
2015-04-27 19:48:28
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cannabis
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Description:
cards for cannabis
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  1. What is the primary active ingredient in cannabis?

    Other important active ingredients?
    delta-9-THC

    cannabanoids - cannabinol (CBN), cannabidiol (CBD)
  2. Hashish:

    Hash oil:
    hashish: resin fr the top of the plant

    hash oil: hashish mixed w oil
  3. Other forms of Cannabis: 

    dronabil - 
    sativex - 
    levonantradol -
    rimonabant-
    synthetic cannabanoids,

    • dronabil - isolated THC
    • sativex - oral spray
    • levonantradol - 30x more potent than thc
    • rimonabant- antagonist to THC
  4. PHARMACOKINETICS

    Smoking - __ - __% into the lungs; __% into the brain

    peak effects at ___ mins
    peak blood lvls at ____ mins

    oral consumption - pKa of ___ = ____ absorption and release
    10-25%; 1%

    • 13-15 mins
    • 15 mins

    10.6 = slow
  5. Anandemide -

    DSI/DSE =
    most common endocannabanoid, works as a neuromodulator

    DSI/DSE = Depolorization induced Supression of Inhibition/Excitability
  6. CB1 active in the ___

    ______ in every system, increased synthesis:
    norepinephrine = ______ effects
    dopamine = _____ effects
    seratonin = _____ efects
    gaba = ____ effects
    CNS

    neuromodulators

    • heart racing
    • reinforcing
    • mood
    • relaxing
  7. CB1 receptors in the brain

    nucelus accumbens =
    cerebellum = 
    hippocampus =
    • n. accumbens = reward center
    • cere = slowed movement effects
    • hippo = slowed memory effects
  8. CB2 in the ____ ; _____
    PNS; immune system
  9. Medically useful peripheral effects:

    eyes, anti-immetic, parkinsons, anorexics, terminal
    induces sleep for pain deprivation

    treatment of glaucoma - changes blood pressure of eyes

    movement disorders

    increased appetite for anorexics

    treatment of terminal illness symptoms
  10. Mood ____ because of ____

    Metabolism differences may cause ____ and ____
    mood INCREASES because of SERATONIN

    Metabolism differences may cause ANXIETY and PARANOIA
  11. Perception - Increase? 
    Alterations in the _____. Pain sensitivity? Time Perception?
    • no increase to sensitivity
    • alterations in the THALAMUS

    loss of pain sensitivity

    altered time perception
  12. Memory - 

    No effect on _____, but problems occur if ____; disrupts _____
    No effect on PREVIOUSLY LEARNED RECALL, but problems occur if TRYING TO LEARN WHILE HIGH; disrupts SHORT TERM MEMORY
  13. Behavior in Nonhumans

    ______ effects on SMA - ___ then ____
    ______ aggression
    ______ effects can be as potent as _______
    ______ generalization to other _______
    BIPHASIC effects on SMA - INCREASE then DECREASES

    DECREASES aggression

    ANALGESIC effects can be as potent as MORPHINE

    PARTIAL generalization to other SEDATIVES
  14. Tolerance 

    Non humans - noticeable in ____ behavior, can last up to a _____

    _____ tolerance can develop, but not to _____ food consumption

    theoretically can be built in ____
    noticeable in OPERANT behavior, can last up to A MONTH

    MOTOR telerance can develop, but not to DECREASE food consumption

    theoretically can be built in 4 DAYS
  15. Self admin patterns of ____ use ____ periods of _____ abstinence
    Self admin patterns of STABLE use WITHOUT periods of IMPOSED ABSTINENCE
  16. Harmful Effects-

    Larger doses can produce _____ symptoms
     
    Damage to the ____ (brain part) with chronic use that is _____ with abstinence

    Reduces ______ (hormone)
    Larger doses can produce PSYCHOTIC symptoms

    Damage to the HIPPOCAMPUS with chronic use that is REVERSIBLE with abstinence

    Reduces TESTOSTERONE

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