CHP. 12 - ANTIPSYCHOTICS

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dsalanga11292
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301650
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CHP. 12 - ANTIPSYCHOTICS
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2015-04-27 21:01:38
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antispsychotics
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cards for chp. 12 - antipsychotics
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  1. schizophrenia
    separation between though, emotion, and behavior in a single personality
  2. Positive Schizophrenic Symptoms
    traits that are abnormally present in psychosis -

    hallucinations, delusions, irrational beliefs, feelings of grandeur, paranoia
  3. Negative Schizophrenic Symptoms:

    affective flattening - 
    anhedonia - 
    avolition -
    traits abnormally absent in psychosis

    affective flattening - person's face is immobile ad unresponsive; emotional repression

    anhedonia - which a person feels no pleasure

    avolition - inability to initiate or engage in goal-directed activites
  4. Neuromorphological Factors of Schizophrenia:

    Lateral and Third Ventricles - 

    Brain Tissue Volume - 

    Synaptic Pruning -
    Lateral and Third Ventricles - nearly 2x as large compared to normal brain

    Brain Tissue Volume - reduced grey matter (corpus colosum, frontal temporal lobes, cerbellum, hippocampus, mesolymbic area

    Synaptic Pruning - weak unused synapses are pruned out and strong ones grow stronger; exaggerated too many connections are pruned
  5. What is the Dopamine Hypothesis?
    Schizophrenia and other psychoses result from excessive dopamine activity in the brain

    too much dopamine in the mesolymbic pathrway; too little in mesocortical
  6. What is the Glutomate Hypothesis?
    glutomate is underactive; too mch at NDMA receptors, too little at AMPA receptors

    genetic factors predispose individual to glutomate hyperactivity, specifically at the NDMA receptor -- man of the genes contributed to the development of schizophrenia
  7. Tardivedyskinesia symptoms
    facial ticks, twitching in muscles, lip smacking, tongue flicking

    permanent, irreversible
  8. EPS effects:

    about __ - __% of __ receptors must be occupied in the basal ganglia to produce EPS
    dulled facial expression,rigid limbs, slowing in movements, loss of coordination

    60-80%
  9. What are Typical Antipsychotics?

    high affinity for what receptors?

    side effects?
    block d1 and d2

    high affinity for d2 and 5-HT2A

    side effects: EPS
  10. What are Atypical Antipsychotics?

    high affinity for what receptors?

    side effects?
    bind to D2 receptors loosely and have dissociiation constants that are significantly higher than typicals

    block D3 and D4, low affinity (bind) for 5TH-2A

    side effects: metabolism, weight issues
  11. Aripiprazole (Abilify) - ______ drug

    __ receptor ____ antagonist 

    ______ rather than ____ dopamine activity at ___, __, and ____ receptors

    ____ and ____ activation where dopamine is ____
    3rd generation

    DA; partial

    modulates; blocks; D2; D3; D4

    binding to; increasing; too high
  12. Pharmacokinetics:

    Administration? 

    Absorption? 

    Typical half life = 
    A-typical half life =

    Competitive with other drugs at _____
    administration: orally, intramuscular

    absorption: first pass metabolism, binds to fats and proteins in blood; slow release, slow excretion

    • typical half life = 28 days
    • a-typical half life = 2-4 days

    competitive with other drugs at cp450
  13. Peripheral Effects of Typical Anti-psychotics
    movement disorders, oversensitivity to sunlight, weight gain, changes in HR, dry mouth, impaired vision, dizziness, increased triglycerides and cholesterol, constipation, jaundice, increased risk of seizure, sedation
  14. Peripheral Effects of A-Typical Anti-Psychotics
    weight gain, increased risk of diabetes, increased triglycerides, dry mouth, dizziness, nausea, cataracts, sedation, sleep apnea
  15. Peripheral Effects of 3rd Gen
    do not effect REM sleep, high TI
  16. Subjective Effects
    NO PLEASANT EFFECTS

    feelings of tiredness, slower and confused thinking, difficulty concentrating, clumsiness, anxiety irritability, internally awake but not externally tired
  17. Effects on Performance
    cognitive deficits related to sedating effects; tolerance can be built
  18. Harmful Effects (reproductive system)
    fertility issues, decreased libido, impaired performance, lactation leakage, abnormal menstrual cycles
  19. Therapeutic Effects
    blocks nausea, helps with motion sickness,

    • treats:
    • hiccups, monoamine induced psychosis, irritability in autistic children

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