Medical Immunology (Exam IV Material) Lecture 14

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mbailey585
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Medical Immunology (Exam IV Material) Lecture 14
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2015-04-29 17:19:04
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Immunology IgE Allergy
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PHS 109: Medical Immunology IgE-Mediated Immunity and Allergy
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  1. Define allergic reaction.
    Hypersensitivity or over-reaction to normally harmless environmental antigens.

    Ex. Plants, animals, or food.
  2. There are four types of hypersensitivity. Which one involves mast cell degranulation and explain the process?

    Give an example of an antigen
    1. Type I

    Hypersensitivity involves mast cell degranulation and begins from antigen binding to IgE on the Fc receptor of mast cells—leading to degranulation and the release of inflammatory mediators.

    2. Plant pollen.
  3. There are four types of hypersensitivity. Which one involves B-cells becoming self reactive and explain the process?

    Give an example of an antigen.
    1. Type II

    Involves the alteration of epitopes that lead to tolerance loss, where B-cells respond with Ab's that are self reactive to newly altered self epitopes.

    2. Penicillin covalently binding to self protein
  4. There are four types of hypersensitivity. Which one is due to soluble immune complexes formed by Ag + Ag-specific IgG and explain the process?

    Give an example of an antigen.
    • 1. Type III
    • Complexes get deposited in blood vessels and alveoli that activate complement leading to the damage of self tissue.

    2. Ab’s generated against proteins from nonhuman animal species
  5. There are four types of hypersensitivity. Which type is caused by Ag-specific T-cells?

    Give an example.
    1. Type IV


    2. Inflammation from TH1 CD4 T cells responding to protein from insect bite/sting

    Inflammation from cytotoxic CD8 T cells responding to chemically modified self-peptide presented on MHC I (mechanism of poison ivy reaction)
  6. What are Type IV allergic reactions referred to as, due to reactions that happen 1-3 days after exposure to antigen?
    Delayed-type hypersensitivity (DTH)
  7. During Type-I hypersensitivity reactions, what does IgE bind to, and what types of cells have these interactions?
    IgE binds to FCεR1 on mast cells, basophils, and eosinophils.
  8. Does IgE require antigen to bind to FCεR1?
    NO. IgE can bind to FCεR1
  9. What is the result of IgE:FCεR1 complexes on mast cells, basophils, and activated esosinophils?
    IgE:FCεR1 complexes effectively provideAg-specific receptors (a characteristic of adaptive immunity) on thesurface of cells of the innate immune system.
  10. How do Type 1 hypersensitivity reactions contrast to B and T cells?
    1. These innate immune cells respond immediately to Ag binding (no proliferation/differentiation phase like lymphocytes)

    2. On a single cell, there can be receptors having different Ag specificities

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