Therapeutics - Toxicities of Chemo 3
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When Leukovorin is given with Methotrexate it makes the risk of Mucositis, Esophagitis and Stomatitis __________.
What is Magic mouthwash and what is it used for?
- Pain relief for Mucositis
- Lidocaine, diphenhydramine and Dicyclomine
What drug is sued to prevent severe mucositis in BM transplant for hematologic malignancies?
What chemo drugs are most likely to cause diarrhea?
- HD methotrexate
What treatments are available for Diarrhea treatment with Chemo drugs?
- Electrolyte replacement
- Loperimide or Lomotil
- Octreotide if refractory
What drugs cause Complete Alopecia?
Paclitaxel or Docetaxel
What drugs are associated with radiation recall?
Doxorubicin, Dactinomycin, Bleomycin, Gemcitabine and Paclitaxel
What drugs cause radiation enhancement when given concurrent or w/in 1 week?
Cisplatin, 5-FU, Gemcitabine, Paclitaxel
What chemo drugs cause photosensitivity?
Dacarbazine, 5-FU, 6-MP, Methotrexate
What cancer drugs cause an Acne-like rash?
- EGFR inhibitors:
What cancer drugs cause Hand-foot syndrome?
What treatment would you give for Edemetous rash?
- Topical anti-inflammatory agent
- Topical or oral antibiotics
- Dose reduce
What treatment would you give for pruritis?
- Topical or oral diphenhydramine
- Oral steroids
- Dose reduce
How do you treat Vinca alkaloid extravasation?
How do you treat Anthracycline extravasation?
How do you treat hypercalcemia initially?
- NS and Fureosemide 200-300 mL/hr for 24-48 hours
- Dialysis if severe renal impairment
What drugs are used to treat hypercalcemia?
- Calcitonin, Pamidrinate, Zoledronic acid and Ibandronate
- Use Calcitonin while waiting for Bisphosphonate to take effect
What drug might you use to stabilize bones with bone metastases?
- Zoledronic acid
What drug is indicated for bone pain with metastases in patients who can’t tolerate bisphosphonates?
What drugs cause Peripheral Neuropathy?
What drugs have a maximum cumulative dose to prevent delayed cardiotoxicity?
- Doxorubicin – most cardiotoxic
You should check ejection fraction prior to using what drugs?
Anthracyclines: - rubicin
What drug is used to bind iron and reduce free radical formation, and thus reduce cardiotoxicity by anthracyclines?
What is the dose for Epoetin alpha (Epogen, Procrit)?
- 150 units/kg 3x/week OR
- 40,000 units weekly OR
- 80,000 units q2weeks OR
- 120,000 units q3weeks
What is the dose for Darbepoetin alpha (Aranesp)?
- 2.25 mcg/kg weekly OR
- 100 mcg/week OR
- 200 mcg q2weeks OR
- 300 mcg q3weeks OR
- 500 mcg q3weeks
What would you like to do?
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