Therapeutics - Targeted Therapies - 1

Card Set Information

Author:
kyleannkelsey
ID:
301928
Filename:
Therapeutics - Targeted Therapies - 1
Updated:
2015-05-01 17:55:53
Tags:
Therapeutics Targeted Therapies
Folders:
Therapeutics - Targeted Therapies
Description:
Therapeutics - Targeted Therapies
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards. What would you like to do?


  1. What are the EGFR inhibitors?
    • Cetuximab
    • Panitumumab
    • Gefitinib
    • Erlotinib
    • Afatinib
    • Sorafenib, TKI & Vandetinib (mixed action)
  2. What are the HER2/Neu inhibitors?
    • Trastuzumab
    • Pertuzumab
    • Lapatinib
    • TKI (mixed)
  3. What are the Bcr-abl inhibitors?
    • Dasatinib
    • Bosutinib
    • Ponatinib
    • Nitotinib
    • Imatinib
  4. What are the ALK inhibitors?
    • Crizotinib
    • Ceritinib
  5. What are the Angiogenesis inhibitors?
    • Bevacizumab
    • Ramucirumab
    • Axitinib, Sorafenib, Regorafenib, Ziv-Aflibercept, Vandetanib, Lenvatinib & Pazopanib (mixed)
  6. What are the Proteasome inhibitors?
    • Bortzomib
    • Carfillzomib
  7. What is the generic name for Avastin:
    Bevacizumab
  8. What is the generic name for Erbitux:
    Cetuximab
  9. What is the generic name for Rituxan:
    Rituximab
  10. What is the generic name for Gleevec:
    Imatinib
  11. What is the generic name for Herceptin:
    Traztuzumab
  12. What is the generic name for Yervoy:
    Ipilimumab
  13. What is the generic name for Tykerb:
    Lapatinib
  14. What is the generic name for Tarceva:
    Erlotinib
  15. What is the brand name for bevacizumab?
    Avastin
  16. What is the brand name for cetuximab?
    Erbitux
  17. What is the brand name for rituximab?
    Rituxan
  18. What is the brand name for imatinib?
    Gleevec
  19. What is the brand name for traztuzumab?
    Herceptin
  20. What is the brand name for ipilimumab?
    Yervoy
  21. What is the brand name for lapatinib?
    Tykerb
  22. What is the brand name for erlotinib?
    Tarceva
  23. What are the CD20 MABs?
    • Rituxumab
    • Ibritumomab tiuxetan
    • Ofatumumab
  24. What are the CTLA-4 mabs?
    Ipilimumab
  25. What does o before –mab mean?
    Mouse
  26. What does xi before –mab mean?
    Chimeric
  27. What does zu before –mab mean?
    Humanized
  28. What does u before –mab mean?
    Human
  29. What type of cells are targeted by Rituimab and what type of killing (indirect or direct) is employed?
    • B cells
    • Indirect
  30. What are the toxicities of Rituximab?
    • Tumor lysis
    • Reactivation of Hep B, CMV, etc.
    • Infusion reactions – slow infusion to prevent, 1st time is worst
    • Anaphylaxis – pretreat w/ APAP and diphenhydramine
  31. What type of cells are targeted by Ofatumumab and what type of killing (indirect or direct) is employed?
    • B-cells
    • Direct
  32. What are the toxicities of Ofatumumab?
    • Infusion reactions
    • Prolonged thrombocytopenia and neutropenia
    • Reactivation of Hep B
    • GI obstruction
    • Severe infections
  33. What drugs cause reactivation of HepB?
    Rituxumab, Obinutuzumab, Ofatumumab
  34. What type of cells are targeted by Obinutuzumab and what type of killing (indirect or direct) is employed?
    • Be cells
    • Direct
  35. What are the toxicities of Obinutuzumab?
    • PML
    • Reactivation of Hep B
    • Prolonged neutropenia
  36. What mabs cause prolonged neutropenia?
    • Obinutuzumab and Ofatumumab
    • Alemtuzumab
  37. How do you prevent infusion reactions with Ofatumumab and Obiutuzumab?
    • Ofatumumab: APAP 100 mg + antihistamine + steroid
    • Obiutuzumab: 1st cycle, APAP 650 mg + Antihistamine + steroid, later cycles just APAP 650 – hold HTN drugs 12 hours prior
  38. What is the indication for Alemtuzumab?
    B cell CLL

What would you like to do?

Home > Flashcards > Print Preview