Therapeutics - Targeted Therapies - 2

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Author:
kyleannkelsey
ID:
301929
Filename:
Therapeutics - Targeted Therapies - 2
Updated:
2015-05-01 17:56:07
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Therapeutics Targeted Therapies
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Therapeutics - Targeted Therapies
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Therapeutics - Targeted Therapies
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  1. How do you prevent infusion reactions w/ Alemtuzumab?
    Premedicate with APAP and Benadryl, may add hydrocortisone
  2. What are the toxicities associated with Alemtuzumab?
    • Prolonged immunosuppression
    • Infusion rxns
  3. You need to prophylax for HSV, PCP and CMV for alemtuzumab, what should you use?
    • HSV: acyclovir or famcycl
    • PCP: Bactrim +/- fungal
    • CMV: Valgancyclovir
  4. What are the major SE for CD targeted mabs?
    • Prolonged immunosuppression
    • Infusion reactions/Anaphylaxis
    • Reactivation of viruses
  5. What is the MOA of ebvacizumab?
    VEGF LIGAND binding antibody
  6. What did the FDA withdrawl approval for Bevacizumab for?
    Breast Cancer
  7. What are the SE of Bevacizumab?
    • GI perforation
    • Delayed wound healing
    • Thrombotic events
    • HTN
    • Bleeding
    • Proteinuria
  8. What is the MOA of Ramucirumab?
    VEGF receptor 2
  9. What are the SE for Ramucirumab?
    • HTN, neutropenia
    • BBW: Hemorrhage
  10. What are the common SE for VEGF inhibitors?
    HTN, bleeding
  11. What are the SE for Cetuximab?
    • Infusion related reactions
    • Acneform rash – starts in 1st week, indicates better prognosis
    • N/V
    • Mucositis
    • Same as Panitumumab
  12. What are the SE for Panitumumab?
    • Infusion related reactions
    • Acneform rash – starts in 1st week, indicates better prognosis
    • N/V
    • Mucositis
    • Same as Cetuximab
  13. What are the SE for EGFR inhibitors?
    • Infusion related reactions
    • Acneform rash – starts in 1st week, indicates better prognosis
    • N/V
    • Mucositis
  14. What are the SE of Trastuzumab?
    • CV events
    • Infusion reactions
    • Rash
    • Myelosupression
  15. What are the SE of Pertuzumab?
    • LV dysfunction
    • Infusion reactions
    • Rash
    • Myelosupression
    • Pregnancy D
  16. What are the general SE of Her2/neu antagonists?
    • Myelosupression
    • Rash
    • Infusion rxns
    • CV – CHF – LV-dysfunction issues
  17. What is the MOA of ipilimumab?
    CTLA-4 – stimulates the immune system to eradicate the cancer
  18. What are the SE of Ipilimumab?
    • Severe and fatal immune reactions due to T cell proliferation
    • Diarrhea, Ab pain and enterocolitis
    • Give high dose steroids to treat
  19. What is the MOA of Nivolumab?
    PD-1 inhibitor – blcoks programed cell death
  20. What are the SE of Nivolumab?
    • Interstitial lung disease/pneumonitis
    • Immune mediated colitis
    • Hepatic and renal issues
    • Endocrine
  21. What small molecule inhibitors are IV?
    • Borezomib
    • Ziv-Aflibercept
    • Carfillzomib
  22. TKIs have what MOA?
    • Involved in cell signaling in:
    • EGFR
    • Her2/Neu
    • c-KIT
    • Bcr-abl
    • Platelet derived growth factor
  23. What are the SE of Gefitinib and Erlotinib?
    • Diarrhea, Acneform rash, interstitial lung disease
    • CYP3A4
  24. What drugs cause and acneform rash?
    • Gefitinib and Erlotinib
    • Cetuximab
  25. What are the toxicities of Afatinib?
    • Diarrhea
    • Ocular changes
    • Interstitial lung disease
  26. What drugs cause interstitial lung disease?
    • Afatinib
    • Lapatinib
    • Trametinib
    • Nivolumab
  27. What are the general SE of EGFR nibs?
    Diarrhea, interstitial lung disease
  28. What are the general SE for Her2/Neu nibs?
    • Hand foot
    • GI
    • Intertitial lung disease
    • LVEF decreases
    • QT prolongation
    • CYP3A4
  29. What are the BRAF inhibitos?
    • Vemurafenib
    • Trametinib
    • Dabrafenib
  30. What are the toxicities of Ibrutinib?
    Bleeding, neutropenia, increase SCR, transient increase in lymphocytes
  31. What is the MOA of Ibrutinib?
    Bruton’s TK – involved in B cell maturation

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