Therapeutics - Lymphoma 1

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Author:
kyleannkelsey
ID:
301940
Filename:
Therapeutics - Lymphoma 1
Updated:
2015-05-01 23:35:26
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Therapeutics Lymphoma
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Therapeutics - Lymphoma
Description:
Therapeutics - Lymphoma
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  1. What histopathology would indicate Hodgkin’s Lymphoma?
    • Reed-Sternberg cell
    • CD30 and CD15
  2. What is Stage I Hodgkin’s Lymphoma?
    Single node or site
  3. What is Stage II Hodgkin’s Lymphoma?
    Two or more lymph node or sites on same side of diaphragm
  4. What is Stage III Hodgkin’s Lymphoma?
    Lymph node involvement on both sides of diaphragm
  5. What is Stage IV Hodgkin’s Lymphoma?
    Diffuse or disseminated involvement of organs/tissues
  6. What is “A” mean in staging Hodgkin’s Lymphoma?
    No fever (asymptomatic)
  7. What is “B” mean in staging Hodgkin’s Lymphoma?
    B-symptoms
  8. What is “X” mean in staging Hodgkin’s Lymphoma?
    • Bulky disease (nodal mass >10 cm)
    • - poor prognosis
  9. What is the chemotherapy regimen for Hodgekin’s Lymphoma?
    • ABVD
    • Adriamycin (Doxorubicin), Bleomycin (pulmonary), Vinblastine, Decarbisine
  10. Adriamycin (Doxorubicin) has what major SE?
    Cardiotoxicity
  11. Bleomycin has what major SE?
    Pulmonary
  12. Vinblastine has what major SE?
    Myelosupression
  13. Decarbisine has what major SE?
    Myelosupression and N/V
  14. What treatment regimen would you use for Early Stage Favorable Hodgekin’s Lymphoma?
    • 4 cycles of ABVD or 2 cycles of Stanford V
    • Restage after
    • Radiation
    • Restage again
  15. What does it mean to be favorable?
    • No fever
    • No B-symptoms
    • No mediastinal mass
  16. What does it mean to be unfavorable?
    • Mediatinal mass
    • Symptomatic
    • Numerous sites of disease
    • Eleveated ESR
    • Poor prognostic factors
  17. What is the treatment for Early stage unfavorable Hodgkin’s Lymphoma?
    • 4 cycles of ABVD or 2 cycles of Stanford V
    • Restage after
    • Radiation
    • Restage again
  18. What treatment is used for advanced stage Hodgkin’s Lymphoma?
    • ABVD or Stanford V
    • BEACOPP for high risk patients (IPS >4)
    • Radiation to minimize bulky disease
  19. What treatments are available for relapsed Hodgkin’s Lymphoma?
    • Autologous stem cell transplant
    • Brentuximab
    • Bendamustine
    • Lenalidomide
  20. What is the MOA of Brentuximab vedotin?
    CD 30+ antibody conjugate w/ auristatin E
  21. When is Brentuximab indicated?
    • After failure of autologous stem cell transplant
    • Failed at least 2 multiagent chemo regimens
  22. What supportive care should be given with Chemo in Hodgkin’s Lymphoma?
    TLS, hydration, electrolytes
  23. What should Chemo patients receive prior to starting?
    Hib, meningococcal and pneumonia vaccines

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