Therapeutics - Lymphoma 2

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Author:
kyleannkelsey
ID:
301941
Filename:
Therapeutics - Lymphoma 2
Updated:
2015-05-01 23:35:40
Tags:
Therapeutics Lymphoma
Folders:
Therapeutics - Lymphoma
Description:
Therapeutics - Lymphoma
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  1. What are the short term effects of chemo in Hodgkin’s Lymphoma/
    • Pulmonary and Cardiac function tests
    • Neurotoxicity
    • Mucositis
    • N/V
  2. What type of lymphoma is a medical emergency?
    Burkitt’s lymphoma
  3. What is the goal for Indolent Lymphoma, limited disease (Stage I or II)?
    Pallaition – no cure
  4. What is the Std treatment for Indolent Lymphoma, limited disease (Stage I or II)?
    • Radiation
    • Chemo controversial
  5. What is the Std therapy for of Indolent lymphoma, Advanced Disease (Stage III and IV)?
    Rituxin based therapy – not curative
  6. What is the treatment for Diffuse Large B-Cell Lymphoma, an aggressive lymphoma: limited disease?
    3-6 cycles of R-CHOP +/- radiation
  7. What is R-CHOP?
    Rituximab - Cyclophosphamide, doxorubicin, vincristine, prednisone
  8. What is the treatment for aggressive lymphoma, Advanced Disease (Stage III and IV)?
    R-CHOP 6 cycles
  9. What is the treatment for relapsed indolent NHL?
    • Rituximab
    • Bendamustine
    • High dose Chemo w/ autologous stem cell rescue
  10. What is the treatment for relapsed aggressive NHL?
    • High dose Chemo w/ autologous stem cell rescue
    • Bendamustine, Brentuximab, etc.
  11. What labs indicate tumor lysis?
    • Hyperkalemia, Hyperphosphatemia and Hyperurecemia
    • Hypocalcemia
  12. How is Hyperkalemia treated in Tumor lysis syndrome?
    Aggressive hydration, calcium gluconate, dextrose, sodium polystyrene sulfonate
  13. How is Hyperphosphatemia treated in Tumor Lysis Syndrome?
    Aluminum hydroxide, sevelamer carbonate
  14. How is Hypocalcemia treated in Tumor Lysis Syndrome?
    Possibly calcium gluconate but resolves with normalization of Phosphate
  15. How is Hyperuresemia treated in Tumor Lysis Syndrome?
    • Hydration, dialysis
    • Allopurinol and rasburicase
  16. Rituxan can cause reactivation of what?
    • Hep B
    • PML (JC virus)
  17. Allopurinol has what MOA?
    Inhibits xanthine oxidase
  18. Rasburicase has what MOA?
    • Recombinant form of urate oxidase
    • Converts uric acid to allantoin which is insoluble
  19. What should you always monitor before therapy for Lymphoma?
    • LVEF
    • Renal function
    • Liver function
    • Neuropathies
    • Blood Sugar

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