Exam 1 — Medical Immunology

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mbailey585
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Exam 1 — Medical Immunology
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2015-05-02 16:09:50
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Immunology
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EXAM I, Course: PHS109 Medical Immunology • Instructor: Guvench • Questions: 39
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  1. Opsonization may involve

    A. CD59
    B. C3
    C. HRF
    D. DAF
    E. C9 polymerization
    B. C3
    (this multiple choice question has been scrambled)
  2. The alternative pathway of complement

    A. Requires hydrolysis of C5 to C5a and C5b
    B. Is activated by an epimer of glucose
    C. Is highly selective for amino groups on pathogens
    D. Relies on covalent attachment of C3b to pathogens
    E. Is initiated by antibodies
    D. Relies on covalent attachment of C3b to pathogens
    (this multiple choice question has been scrambled)
  3. Which of the following types of epithelia allows the least overall passage of molecules and cells?

    A. Small intestine
    B. Skin
    C. Lung
    D. Large intestine
    E. Mouth
    B. Skin
    (this multiple choice question has been scrambled)
  4. An IgG molecule has approximately how many amino acids?

    A. 110
    B. 5500
    C. 1200
    D. 500
    E. 50
    C. 1200
    (this multiple choice question has been scrambled)
  5. Approximately what year was smallpox officially eradicated?

    A. 1790
    B. 1950
    C. 1900
    D. 2010
    E. 1980
    E. 1980
    (this multiple choice question has been scrambled)
  6. A discontinuous epitope

    A. Depends on the fold of the protein it is part of
    B. Consists of ~30 amino acids
    C. Consists of ~30 amino acids
    D. Has multivalent antigens
    E. Must be part of a proteinMust be part of a nucleic acid
    A. Depends on the fold of the protein it is part of
    (this multiple choice question has been scrambled)
  7. The commensal bacteria in and on a normal healthy human

    A. Are not required for good health
    B.  present before birth
    C. Provide a mechanical barrier
    D. Outnumber human cells by 10 to 1
    E. Do not pose a risk of infection
    D. Outnumber human cells by 10 to 1
    (this multiple choice question has been scrambled)
  8. Lack of a spleen significantly increases the risk for

    A. Fungal skin infections
    B. Bacterial blood infections
    C. Intestinal worms
    D. HIV/AIDS
    E. Viral respiratory infections
    B. Bacterial blood infections
    (this multiple choice question has been scrambled)
  9. A healthy adult human gut has approximately how much bacteria?

    A. 1 gram
    B. 100 grams
    C. 10 pounds
    D. 1 pound
    E. 10 grams
    C. 10 pounds
    (this multiple choice question has been scrambled)
  10. All of the following are true of Type I interferons IFN-alpha and IFN-beta EXCEPT:

    A. They suppress NK cell cytotoxicity
    B. They can directly interfere with viral replication
    C. They can act in both an autocrine and a paracrine fashion
    D. They are produced in large quantities by plamacytoid dendritic cellsThey are cytokines
    A. They suppress NK cell cytotoxicity
    (this multiple choice question has been scrambled)
  11. Sialyl Lewis-X (s-LeX) is

    A. A ligand for selectins
    B. A ligand for the CXCL8 chemokine receptor
    C. The preferred means to dissolve basement membrane
    D. The primary mediator of neutrophil tight binding and diapedesis
    E. Another name for ICAM-1
    A. A ligand for selectins
    (this multiple choice question has been scrambled)
  12. Which of the following is true with regard to adaptive immunity?

    A. Is required to initiate an innate immune response 
    B. Consists of natural killer cells
    C. Relies exclusively on receptors with broad specificity
    D. Is effective within hours of when the host encounters a pathogen for the first time
    E. Is unique to vertebrate animals
    E. Is unique to vertebrate animals
    (this multiple choice question has been scrambled)
  13. A proteoglycan consists of

    A. A core protein with nucleic acid chains
    B. A core carbohydrate with peptide chains
    C. A core protein with glycosaminoglycan chains
    D. A core nucleic acid with peptide chains
    E. A core lipid with carbohydrate chains
    C. A core protein with glycosaminoglycan chains
    (this multiple choice question has been scrambled)
  14. Pathogens that can EXCLUSIVELY be extracellular include all of the following EXCEPT:

    A. Viruses
    B. Multicellular parasites
    C. Bacteria
    D. Fungi
    A. Viruses
    (this multiple choice question has been scrambled)
  15. Formation of the iC3Bb convertase involves all of the following EXCEPT:

    A. Nucleophilic attack
    B. Thioester hydrolysis
    C. Factor D
    D. Factor B
    E. Release of C3a
    E. Release of C3a
    (this multiple choice question has been scrambled)
  16. A serine protease

    A. Catalyzes oxidation of serine side chains
    B. Forms a thioester
    C. May be a complement protein
    D. Is a specialized type of nucleic acid
    E. Catalyzes reduction of serine side chains
    E. Catalyzes reduction of serine side chains
    (this multiple choice question has been scrambled)
  17. All of the following are true EXCEPT:

    A. Commensal bacteria are not opportunistic pathogens
    B. Death of commensal bacteria by antibiotics can lead to opportunistic infections
    C. If a host is weakened, an opportunistic pathogen can cause disease
    D. If allowed into a part of the host’s body where it is normally not present, an opportunistic pathogen can cause disease
    E. An opportunistic pathogen can be present in the body with no ill effect
    A. Commensal bacteria are not opportunistic pathogens
    (this multiple choice question has been scrambled)
  18. A major component of netosis is

    A. Negatively-charged macrophage proteins
    B. The death of natural killer cells
    C. Chromatin
    D. The clearing of intracellular viral infection
    E. Viral transcription
    C. Chromatin
    (this multiple choice question has been scrambled)
  19. Which of the following is NOT a “successful” pathogen?

    A. Measles
    B. Ebola
    C. Malaria
    D. Chickenpox
    E. Influenza
    B. Ebola
    (this multiple choice question has been scrambled)
  20. The “ab” in “Fab” stands for

    A. Aerosolizable
    B. Absolute
    C. Affinity blotting
    D. Antibody
    E. Antigen binding
    E. Antigen binding
    (this multiple choice question has been scrambled)
  21. Which of the following is a circulating precursor to a macrophage?

    A. Megakaryocyte
    B. Natural killer cell
    C. Monocyte
    D. Red blood cell
    E. Eosinophil
    C. Monocyte
    (this multiple choice question has been scrambled)
  22. All of the following are associated with adaptive immunity EXCEPT:

    A. Response within minutes to an unfamiliar pathogen
    B. Immunological memory
    C. “Protective” immunity
    D. Highly selective receptors involving changes to germline DNA
    E. “Acquired” immunity
    A. Response within minutes to an unfamiliar pathogen
    (this multiple choice question has been scrambled)
  23. All of the following are true of monoclonal antibodies EXCEPT

    A. They are produced from cancerous cells
    B. They can be used to label cells
    C. They are used to define a cluster of differentiation
    D. They have a single antigen binding site
    E. They can be used as therapeutics
    D. They have a single antigen binding site
    (this multiple choice question has been scrambled)
  24. Examples of primary lymphoid tissue include

    A. Spleen
    B. Appendix
    C. Adrenals
    D. Liver
    E. Thymus
    E. Thymus
    (this multiple choice question has been scrambled)
  25. Another name for the pain associated with inflammation is:

    A. Dolor
    B. Tumor
    C. Calor
    D. Rubor
    A. Dolor
    (this multiple choice question has been scrambled)
  26. Clonal expansion can refer to:

    A. Increase in the number of cells in a lymphocyte clone
    B. Production of complement by the liver
    C. Selection of a particular lymphocyte to combat an infection
    D. Release of stored neutrophils from the bone marrow
    E. Differentiation of a granulocyte precursor into a basophil
    B. Production of complement by the liver
    (this multiple choice question has been scrambled)
  27. Which of the following lacks flexible polypeptides between the Fab and Fc regions?

    A. G
    B. M
    C. D
    D. A
    B. M
    (this multiple choice question has been scrambled)
  28. With regard to a particular normal, healthy human:

    A. A neutrophil will regenerate its granules after combatting infection
    B. One macrophage may express different innate immune receptors than another
    C. One natural killer cell may have altered genetics relative to another
    D. Natural killer cells induce necrosis in virus-infected epithelium
    E. Lectins are polymers of simple carbohydrates
    B. One macrophage may express different innate immune receptors than another
    (this multiple choice question has been scrambled)
  29. Chimeric antibodies

    A. Have mouse genetics in the V domains and human genetics in the C domains
    B. Have human genetics in the V and the C domains
    C. Have mouse genetics in the V and the C domains
    D. Have human genetics in the V domains and mouse genetics in the C domains
    A. Have mouse genetics in the V domains and human genetics in the C domains
    (this multiple choice question has been scrambled)
  30. Sources of commensal microbiota for humans include all of the following EXCEPT:

    A. Vaginal birth
    B. Playing in the dirt
    C. Pets
    D. Vaccination
    E. Family members
    D. Vaccination
    (this multiple choice question has been scrambled)
  31. A zymogen

    A. Is inactive
    B. Is a kinase
    C. Raises the activation energy of a reaction
    D. Changes the equilibrium constant of a reaction
    E. Is a phosphatase
    A. Is inactive
    (this multiple choice question has been scrambled)
  32. Lymph returns to the venous circulation through the

    A. Right pulmonary veins
    B. Tonsils
    C. Peyer’s patches
    D. Hepatic portal vein
    E. Left subclavian vein
    E. Left subclavian vein
    (this multiple choice question has been scrambled)
  33. “Vaccinia” refers to

    A. cowpox virus
    B. polio virus
    C. measles virus
    D. smallpox virus
    E. flu virus
    A. cowpox virus
    (this multiple choice question has been scrambled)
  34. The lymphoid progenitor gives rise to

    A. Platelets
    B. Mast cells
    C. Natural killer cells
    D. Erythroblasts
    E. Monocytes
    C. Natural killer cells
    (this multiple choice question has been scrambled)
  35. Hypervariable loops

    A. Are located at the interface between the V and C Ig domains
    B. Are highly conserved within a species
    C. Are also known as CDR loops
    D. Exist in pairs of 3’s because of homodimerization
    E. Connect the antigen binding beta strands of the V domain
    C. Are also known as CDR loops
    (this multiple choice question has been scrambled)
  36. All of the following are true of Toll-like receptors (TLRs) EXCEPT:

    A. TLR4 homodimer can recognize Gram-negative bacteria
    B. TLR pathogen recognition may be extracellular or intracellular
    C. TLR genes are recombined in macrophages to increase TLR diversity
    D. TLR signaling leads to gene expression
    E. TLR signaling leads to a kinase cascade
    C. TLR genes are recombined in macrophages to increase TLR diversity
    (this multiple choice question has been scrambled)
  37. The “leakiness” of activated endothelium can be due to all of the following EXCEPT:

    A. Gaps between neighboring endothelial cells
    B. Endothelial cell-surface expression of sialyl Lewis X
    C. Protease activity by granulocytes
    D. Macrophage activation
    E. Endothelial response to cytokines
    B. Endothelial cell-surface expression of sialyl Lewis X
    (this multiple choice question has been scrambled)
  38. For a given infection, a person lacking innate immunity

    A. Will produce more antibodies against the infection than a normal person would
    B. Will likely be overcome quickly by the infection
    C. Will still have a normal immediate innate response
    D. Will still have a normal induced innate response
    E. Will successfully fight the infection with adaptive immunity
    B. Will likely be overcome quickly by the infection
    (this multiple choice question has been scrambled)
  39. Acute phase proteins include

    A. IL-1beta receptor
    B. C-reactive protein
    C. Azurophilic granules
    D. Neutrophil lysozyme
    E. Antibodies
    B. C-reactive protein
    (this multiple choice question has been scrambled)

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