Hem Lec 21

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CTEPBA
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302198
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Hem Lec 21
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2015-05-05 16:12:36
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Hem Lec 21
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Hem Lec 21
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  1. MPNs are characterized by all of the following except?
    initial increase of immature cells
  2. In CML, the total leukocyte (WBC) count is?
    extremely increased
  3. Which of the following is a remarkable characteristic of PV compared with other types of MPNs?
    Extremely increased erythrocyte mass
  4. Which of the following is a predominant feature of essential thrombocythemia compared with other types of MPNs?
    Extremely increased number of platelets
  5. In MPN, the test results of disorders of hemostasis and coagulation that are most likely to be abnormal are?
    increased APTT, decreased factor V level, andincreased concentration of antithrombin III inmany
  6. Interferon alfa has been shown to?
    suppress proliferation of hematopoietic progenitor cells
  7. A leukemia of long duration that affects the neutrophilic granulocytes is referred to as?
    CML
  8. The alkaline phosphatase cytochemical staining reaction is used to differentiate? between
    CML and severe bacterial infections
  9. Patients with the initial phase of CML are prone to?
    • low-grade fevers
    • night sweats
    • splenic infarction
  10. The total leukocyte count in CML usually is _____ ×109/L.
    >50
  11. The Philadelphia chromosome is typically associated with?
    CML
  12. Patients with PV suffer from?
    hypervolemia
  13. Hyperviscosity can produce?
    dizziness
  14. The major criteria for diagnosis of PV include all of the following except?
    splenomegaly
  15. Increased blood viscosity in patients with PV can causea dangerous condition of
    vascular occlusion
  16. Treated patients with PV have a _____ life expectancy after diagnosis.
    more than 10-year
  17. The primary treatment for PV is?
    therapeutic phlebotomy
  18. The predominant clinical manifestation of primary myelofibrosis is?
    • anemia
    • splenomegaly
    • medullary fibrosis
  19. The median survival time for patients with primary myelofibrosis is approximately _____ year(s).
    5
  20. The least common form of MPN is?
    essential thrombocythemia
  21. A major criterion for the diagnosis of essential thrombocythemia is?
    persistent increase of platelets in peripheral blood
  22. The most common disorder in patients with essential thrombocythemia is
    neurological manifestations
  23. The bone marrow architecture in essential thrombocythemia is similar to the architecture seen in?
    CML

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