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Hem Lec 21
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MPNs are characterized by all of the following except?
initial increase of immature cells
In CML, the total leukocyte (WBC) count is?
extremely increased
Which of the following is a remarkable characteristic of PV compared with other types of MPNs?
Extremely increased erythrocyte mass
Which of the following is a predominant feature of essential thrombocythemia compared with other types of MPNs?
Extremely increased number of platelets
In MPN, the test results of disorders of hemostasis and coagulation that are most likely to be abnormal are?
increased APTT, decreased factor V level, andincreased concentration of antithrombin III inmany
Interferon alfa has been shown to?
suppress proliferation of hematopoietic progenitor cells
A leukemia of long duration that affects the neutrophilic granulocytes is referred to as?
CML
The alkaline phosphatase cytochemical staining reaction is used to differentiate? between
CML and severe bacterial infections
Patients with the initial phase of CML are prone to?
low-grade fevers
night sweats
splenic infarction
The total leukocyte count in CML usually is _____ ×10
9
/L.
>50
The Philadelphia chromosome is typically associated with?
CML
Patients with PV suffer from?
hypervolemia
Hyperviscosity can produce?
dizziness
The major criteria for diagnosis of PV include all of the following except?
splenomegaly
Increased blood viscosity in patients with PV can causea dangerous condition of
vascular occlusion
Treated patients with PV have a _____ life expectancy after diagnosis.
more than 10-year
The primary treatment for PV is?
therapeutic phlebotomy
The predominant clinical manifestation of primary myelofibrosis is?
anemia
splenomegaly
medullary fibrosis
The median survival time for patients with primary myelofibrosis is approximately _____ year(s).
5
The least common form of MPN is?
essential thrombocythemia
A major criterion for the diagnosis of essential thrombocythemia is?
persistent increase of platelets in peripheral blood
The most common disorder in patients with essential thrombocythemia is
neurological manifestations
The bone marrow architecture in essential thrombocythemia is similar to the architecture seen in?
CML
Author
CTEPBA
ID
302198
Card Set
Hem Lec 21
Description
Hem Lec 21
Updated
5/5/2015, 8:12:36 PM
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