chromosome aberrations and cancer

Card Set Information

Author:
jen
ID:
302211
Filename:
chromosome aberrations and cancer
Updated:
2015-05-18 21:11:40
Tags:
cancer cytogenetics
Folders:
cytogenetics
Description:
cancers and associated chromosomal anomalies
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  1. Burkitt/Burkitt-like lymphoma
    • t(8;14)(q24.1;q32)
    • IGH-MYC
  2. Follicular lymphoma
    • t(14;18)(q32;q21)
    • IGH-BCL2
  3. Diffuse large cell lymphoma
    • t(3;14)(q27;q32)
    • BCL6-IGH

    *variants: t(2;3)(p12;q27)[IGK-BCL2] and t(3;22)(q27;q11.2)[BCL6-IGL] or t(14;18) detected in follicular lymphoma
  4. Small Lymphocytic Lymphoma
    trisomy 12 (also +3,+18)
  5. Lymphoplasmacytic lymphoma
    t(9;14)(p13;q32)
  6. Mantle cell lymphoma
    • t(11;14)(q13;q32)
    • BCL1-IGH
  7. Hodgkin lymphoma
    • polyploidy
    • trisomies 1,3,7,8,21 + recurrent structural aberrations
  8. Marginal Zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)
    • t(11;18)(q211;q21)
    • API1-MALT1
  9. Splenic MZBCL
    deletion 7q
  10. Anaplastic large cell lymphoma (T-cell)
    • t(2;5)(p23;q35)
    • ALK1-NPM
  11. Lymphoblastic T-cell lymphoma
    • 14q11 rearrangments involving TCRA and TCRD
    • t(11;14)(p13;q11.2)
    • t(8;14)(q24.1;q11.2)
    • inv14(q11.2q32)
  12. Ewing Sarcoma
    • t(11;22)(q24;q12)
    • EWS-FLI1
  13. Mixoid liposarcoma
    t(12;16)(13;q11)
  14. Clear cell sarcoma
  15. Congenital Fibrosarcoma
  16. Alveolar Soft Part Sarcoma

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