Body depletes carbohydrates
first then uses reserves from liver and muscle but initially spares protein
2. Gluconeogenesis in liver:
Amino acid converted from protein and now made into glucose, Called being in negative nitrogen balance
(Defined as increased rate of protein breakdown vs. protein synthesis. Nitrogen excretion exceeds nitrogen intake)
3. Body fat is mobilized:
within 5-9 days of malnutrion; body is still trying to spare protein
. Fat stores are depleted and body proteins used for energy 4-6 weeks
. Protein depletion
causes liver function to be impaired and synthesis of protein decreases. If there's no protein, then liver can't make albumin!!
7 Decreased oncotic pressure
leads to edema and electrolyte/fluid shifts --ascites
8 Failure of the sodium-potassium exchange pump
can lead to life-threatening electrolyte imbalances=HYPERkalemia
that can cause arrythmias. Potassium cannot get into the cell.
- 9 Continued organ dysfunction can eventually lead to death )
- marasnus: form of severe malnutrion characterized as energy deficiency; body weight is reduced to 60% of normal bodyweight for that age; like severly anorexic!