-
four stages of early development
cleavage: mitotic divisions
implantation: embryo implants during blastula stage
gastrulation: ectoderm, endoderm, and mesoderm
neurulation: germ layers develop a NS
-
Ectoderm
- NS
- epidermis
- lens of eye
- inner ear
-
mesoderm
- muscles
- skeleton
- circulatory system
- gonads
- kidneys
-
endoderm
- lining of digestive tract
- lungs
- liver
- pancreas
-
Liver's role in homeostasis
- gluconeogenesis
- processing of nitrogenous wastes (urea)
- detoxification of wastes/ chemicals/ drugs
- storage of iron and vitamin A
- synthesis of bile and blood proteins
- beta-oxidation of fatty acids to ketones
- interconversion of carbohydrates, fats, adn amino acids
-
layers of skin
- stratum..
- - corneum
- - lucidum
- - granulosum
- - spinosum
- - basalis
-
aldosterone
stimulates Na+ reabsorption, K+ and H+ secretion, increasing water reabsorption, blood volume, and blood pressure
secreted from adrenal cortex
is regulated by the renin-angiotensin-aldosterone system
-
ADH (vasopressin)
- increases collecting duct's permeabilit to water to increase water reabsorption
- --> is secreted from posterior pituitary with high [solute] in the blood
Kidneys: regulate [salt] and [water] in the blood; functional unit is the nephron
-
peptide hormones
act via second messengers
-
steroid hormones
act via hormone/ receptor binding to DNA
-
Anterior pituitary secretes what?
- FSH
- LH
- Adrenocorticotropic (ACTH)
- prolactin
- endorphins
- GH
-
FSH
stimualtes follicle maturation; spermatogenesis
-
LH
stimulates vulation; testosterone synthesis
-
ACTH
stimulates adrenal cortex to make and secrete glucocorticoids
-
TSH
stimulates the thyroid to produce thyroid hormones
-
prolactin
stimulates milk production and secretion
-
endorphins
inhibits the perception of pain in the brain
-
growth hormone
stimulates bone and muscle growth/ lipolysis
-
hypothalamus; stored in the posterior pituitary
- oxytocin
- ADh (vasopressin)
-
oxytocin
stimulates uterine contractions during labor, milk secretion during lactation
-
ADH
stimulates water reabsorption in kidneys
-
Thyroid
T3, T4
calcitonin
-
T3, T4
stimulates metabolic activity
-
calcitonin
decreases (tones down) blood calcium level
-
Parathyroid
PTH: increases blood calcium level
-
Adrenal Cortex
glucocorticoids: increase blood glucose level and decreases protein synthesis; anti-inflammatory
mineralocorticoids: increases blood glucose level and heart rate
-
Pancrease
glucagon: stimulates conversion of glycogen to glucose in the liver; increases blood glucose
insulin: lowers blood glucose; increases glycogen stores
somatostation: suppresses secretion of glucagon and insulin
-
Pineal
melatonin: regulates sleep-wake cycles
-
heart
atrial natriuretic peptide: involved in osmoregulation and vasodilation
-
Thymus
thymosin: stimulates T-cell development
-
Contraction
initiation
sarcomere shortening
relaxation
initiation: depolarization of a neuron leads to an action potential
sarcomere shortening: sarcoplasmic reticulum releases Ca2+; Ca2+ binds to troponin on the actin filament; tropomyosin shifts, exposing myosin-binding sites; myosin binds, ATPase activity allows myosin to pull thin filaments towards the center of the H zone, and then ATP cases dissociation
relaxation: Ca2+ is pumped back into the SR
-
Reformation
inorganic ions are absorbed from the blood for use in bone
-
degradation (resorption)
inorganic ions are released into the blood
-
Three portal systems
blood travels through an extra capillary bed before returning to the heart
- liver (hepatic)
- kidney
- brain (hypophyseal)
-
fetal circulation
foramen ovale: connects right and left atria
ductus arteriosus: connects pulmonary artery to aorta; along with foramen ovale, shunts blood away from lungs
ductus venosus: connects umbilical vein to inferior vena cava, connecting umbilical circulation to central circulation
-
plasma
aqueous mix of nutrients, wastes, hormones, blood proteins, gases, and salts
-
humoral immunity
Beta lymphocytes--->
- memory cells: remember antigen, speed up secondary response
- plasma cells: make and release antibodies (IgG, IgA, IgM, IgD, and IgE) which induce antigen phagocytosis
-
active immunity
antibodies produced during an immune response
-
passive immunity
antibodies prodcued by one organism are transferred to another oganism
-
cell-mediated immunity (specific defense)
- t-lymphocytes-->
- 1) cytotoxic T cells
- 2) helper T cells: activate B- and T-cells and macrophages by secreting lymphokines
- 3) suppressor T-cells: regulate B-and T-cells to decrease anti-antigen activity
- 4) memory cells
-
Nonspecific immune response
includes skin, passages lined with cilia, macrophages, imflammatory response, and interferons
-
Lipid Digestion
- 1) Chyme present--> duodenum secretes CCK into blood
- 2) CCK stimulates secretion of pancreatic enzymes and bile, and promotes atiety
- 3) Bile made in liver and emulsifies fat in small intestine
- 4) Lipase made in pancrease; hydrolyzes lipids
-
Protein digestion
- enzymes in the pancreas
trypsin: converts chymotrispinogen to chymotrpsin
chymotripsin
carboxypeptidases A and B: hyrolyzes terminal peptide bond at C-termimus
-
Protein digestion
- intestinal glands
aminopeptidase
dipeptidase
enteropeptidase
|
|