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pyloric glands
contain G cells that secrete gastrin, whcih induces parietal cells to secrete more HCl and signals the stomact to contract and mix its content
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What does the presence of chyme cause?
causes brush border enzymes to secrete disaccharidases
duodenum secretes enteropeptidase, whcih activtes trypsin
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secretin
peptide hormone that causes pancreatic enzymes to be released into the duodenum
regulates the pH of the digestive tract by reducing HCl secretion
it is an enterogastrone (hormone that slows motility through the digestive tract)
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CCK
stimulates secretion of bile
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Where else beside the mouth are fats digested?
small intestine with pancreatic lipase
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bilirubin
major pigment of bile
travels to the liver, where it is conjugated and secreted into the bile for excretion
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Process of amino acids and carbos through small intestine.
secondary active transport and facilitated diffusion into the epithelial cells lining the small intestine; they then move across the epithelial cells into the intestinal capillaries; a concentrationg radient then lalows simple carbs and amino acids to diffuse into capillaries
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cecum
an outpocketing that accepts fluid exiting hte small intestine through the ileocecal valve and is the site of the appendix
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Bowman's capsule
cuplike structure surrounding the nephron
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micturition reflex
relaxation of the urethral sphincter in response to increased pressure in the bladder
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Where is hydrostatic pressure higher, glomerululs or Bowman's capsule?
glomerulus
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What does the liver do to ammonia?
converts it to urea
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Reabsorption
reuptake for use in the bod
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Explain a tip for the kidney structure.
segments that are horizontal are focused ont eh the identity of teh particles (keep what is needed; lose what is not)
vertical: focused on volume adn concentratoin
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proximal convoluted tubule
amino acids, glucose, water-soluble, vitamins,and salts are reabsorbed along with water
70% reabsorbed
site of secretion for a number of waste products, including hydrogen ions, potassium, ammonia, and urea
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descending limb of the loop of Henle
permeable only to water adn the medulla has an ever increasing osmolarity
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ascending limb of the loop of Henle
change in permeability; only permeable to salts and not water
increasing amounts are removed as it travels up
thicker diluting segment (cells lining the tube are larger)
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Explain the diluting segment
cells are larger; contain large amounts of mitochondria, which allow reabsorption of Na+ and Cl- by active transport
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Distal convoluted tuule
responds to aldosterone, which promoes sodium reabsorption
sodium ions are osmotically active particles so water will follow, concentating the urine
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collecting duct
responsive to aldosterone and ADH
permeability increases--> water reabsorption
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What are the functions of the kidneys?
control BP, blood osmolarity, and acid-base balance
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What does aldosterone work on?
distal CT
collecting duct
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What does ADH work on?
alters permeability of collecting duct directly, allowing more water to be reabsorbed by making the cell junctions of the duct leaky
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dermis
papillary layer
reticular layer
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Merkel cells
sensory cells present at the epidermal-dermal junction; connected to sensory neurons and are responsible for deep pressure and texture sensation within the skin
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Meissner's corpuscles
respond to light touch
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Ruffini endings
respond to stretch
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Pacinian corpuscles
respond to deep pressure and vibration
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arector pili
muscles that contract in cold conditions causing hair to stand up
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What does cardiac muscle have?
gap junctions that allow for flow of ions directly between cells
this allows for coordinated muscle cell depolarization and efficient contraction of cardiac muscle
gap junctions allow for progressive depolarization to spread via ion flow across the gap junctions between cells
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I band
contains mostly thin flimaents
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A-band
contains the thick filaments in their entirety, including any overlap with think filaments
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H zone
contains only thick filaments
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Explain muscle contraction
- contraction starts at the neuromuscular junction, where the NS communicates with motor neurons
- The signal travels down neuron until it reaches the nerve teerminal, where acetylcholine is released into the synapse
acetylcholine binds to receptors on the sarcolemma, causing depolarization
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Troponin and tropomyosin
calcium binds to troponin, causing a change in conformaiton of tropomyosin, allowing exposure of myosin binding sites
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ATP bound to myosin causes what?
release of myosin from actin
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frequency summation
if a muscle fiber is exposed to frequent and prolonged summation, it will have insufficient time to relax; the contractions combine, become stronger and more prolonged
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fast twitch muscles form of energy?
have less mitochondria and rely on glycolysis and fermentation to make ATP under most circumstances
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long bones
cyclindrical shafts called diaphyses that swell at each end to form metaphyses and that terminate in epiphyses
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epiphyses
se spongy cores for more effective dispersion of force andpressure at joins; at internal edge is an epiphyseal growth plate, which is a cartilaginous structure and the site of longitudinal growth
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Synovium
a laer of soft tissue that secretes synovial fluid, which lubricates the movement of structures in the joint space
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flexor
muscle that decreases the angle across a joint
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extensor
increases or straightens this angle
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abductor
moves a part of the body away from teh midline
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adductor
moves part of body toward midline
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penetrance
population measure defined as the proportion of individuals in the population carrying the allele who actually express the phenotype
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full penetrance
when 100% of individuals with the allele show symptoms
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high penetrance
most but not all show symptoms of the disease
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expressivity
varying phenotypes despite identical genotypes
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If expressivity is constant, then what?
all individuals with a given genotype express the same phenotype
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Mendel's first law
genes exist in alternative forms called alleles
an organism has two alleles for each gene, one inherited from each parent
the two alleles segregate during meiosis, resuting in gametes that carry only one allele for any inherited trait
if two alleles are different, one is fully expressed and the other is silent
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duplication mutations
occur when a segment of DNA is copied multiple times in the genome
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inversion mutations
occur when a segment of DNA is reversed within the chromosome
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insertion mutations
occur when a segment of DNA is moved from one chromosome to another; small insertion mutations are considered frameshift mutations
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translocation mutations
occur when a segment of DNA from one chromosome is swapped with a segment from another
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genetic leakage
- flow of genes between species
- individuals from different species can mate to produce hybrid offspring, which can't reproduce
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founder effect
extreme case of genetic drift in which a small population of a species finds itself in reproductive isolation from other populations as a result of natural barriers, catastrophes, or other bottleneks that drastically and suddenly reduce the size of the population available for breeding
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genetic drift
changes in the composition of the gene pool due to chance
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inbreeding depression
loss of genetic variation that may cause reduced fitness of the population
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outbreeding/ outcrossing
intro of unrelated individuals into a breeding group
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bottleneck effect
The bottleneck effect is a sharp lowering of a population's gene pool because of an environmental, or human-caused, change
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recombination frequency
the likelihood that two alleles are separated from each other during crossing over
roughly proportional to the distance between the genes on the chromosome
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allele frequency
how often an allele appears in a populaiton
ex: if 75 alleles were dominate out of 100, there is a .75 frequency
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Wat criteria must be met for the gene pool to be stable and evolution to not be occurring?
population is very large (no genetic drift)
no mutations
mating is random
no migration of individuals into or out of the population
genes are equally successful at reproducing
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modern synthesis model
adds knowledge of genetic inheritance and changes in the gene pool to Darwin's original heory
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inclusive fitness
measure of an organism's success in teh population
altruism is a component of inclusive fitnesss that is helping others because it will increase your sucess
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punctuated equilibrium
suggests that changes in some species occur in rapid bursts rather than evenly over ime
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stablilizing selection
keeps phenotypes within a specific range by selecting against extremes
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directional selection
adaptive pressure can lead to the emergence and dominance of an initially extreme phenotype
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disruptive selection
two extreme phenotypes are selected over the norm
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adaptive radiation
related concept of dirsuptiv selection that describes the rapid rise of a number of differnt species from a common ancestor that enables animals to occupy certain niches
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prezygotic mechanisms include...
- temporal isolation (breeding at different times)
- ecological isolation
- behavioral isolation (lack of attraction)
- gametic isolation (fertilization not possible)
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postzygotic mechanisms include...
- hybrid inviability
- hybrid sterility
- hybrid breakdown
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