Which of the following conditions is associated with hyponatremia?
A. Diuretic therapy
B. Cushing’s syndrome
C. Diabetes insipidus
D. Nephrotic syndrome
Diuretics lower blood pressure by promoting water loss. This is accomplished by causing sodium loss from the proximal tubule and/or loop. Addison’s disease, syndrome of inappropriate ADH release, burns, diabetic ketoacidosis, hypopituitarism, vomiting, diarrhea, and cystic ﬁbrosis also cause hyponatremia. Cushing’s syndrome causes hypernatremia by promoting sodium reabsorption in the collecting tubule in exchange for potassium. Diabetes insipidus and nephrotic syndrome promote hypernatremia by causing water loss.