Ch1 2 Pharm

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Ch1 2 Pharm
2015-06-09 13:49:31
Ch1 Pharm

Ch1 2 Pharm
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  1. Schedule II controlled substances
    • Morphine
    • amphetamine derivatives
  2. Schedule III controlled substances
    • Mild to moderate dependence potential
    • Codeine
    • anabolic steroids
    • amphetamines
  3. Schedule IV controlled substances
    antianxiety drugs
  4. Schedule V controlled substances
    • low dose of opioids in cough medications
    • antidiarrheal preparations
  5. Dose/Dosage based on
    • Enough to do the job intended
    • Minimal toxic effects
  6. Ceiling effect or maximal efficacy
    Increasing dose wont give greater effect
  7. Range of effectiveness
    • Threshold dose
    • ----The response begins to occur
    • Celling effect/ maximal effect
    • ----When there is no further increase in response
    • Shape of dose response curve and pressure of the plateau associated with maximal efficacy can be used to dictate specific information about the binding of a drug to a receptor
  8. Potency
    • Dose that produces a given response of a specific amplitude
    • More potent drug needs lower dose to provide same effect
  9. Quantal-dose response curve
    Increased responsiveness in the population
  10. Median effective dose (ED50)
    50% of the population responds in the expected manner
  11. Median toxic dose (TD50)
    Dosage where 50% of the population exhibit toxic effects
  12. Therapeutic index
    • Indicator of drug safety
    • Greater the TI greater the safety (prescriptions have low TIs)
    • Calculation based on median effective and median toxic doses:
    • TI = TD50
    • ED50