Ch 4 1 Pharm

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Author:
jld15
ID:
303858
Filename:
Ch 4 1 Pharm
Updated:
2015-06-09 14:54:12
Tags:
Pharm
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Description:
Ch 4 1 Pharm
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  1. Drug receptors locations
    • Surface receptors linked to ion channels
    • Surface receptors linked to enzymes
    • Surface receptors linked to G proteins (2nd messenger)
    • Intracellular receptors
  2. Ion Channels
    • Alter cell membrane permeability
    • Depolarization of cell occurs – allowing influx of various ions
    • Examples:
    • ----Acetylcholine
    • ----GABA
  3. Enzymes
    • Extracellular receptor site
    • Intracellular enzymatic component
    • Examples:
    • ----Insulin
    • ----Growth factors
  4. Regulatory Proteins
    • Intermediate regulatory protein
    • G proteins
    • ----Guanine nucleotides
    • ----Stimulatory or inhibitory
    • Second messenger
    • Related with
    • ----Alcoholism
    • ----Tumors
    • ----DM
    • ----Heart failure
  5. Intracellular Receptors
    • Located in cells (cytoplasm)
    • Drug binds to specific genes within the cell
  6. Affinity
    Attraction btwn drug and receptor
  7. Efficacy
    If the drug is trying to make a change
  8. Selectivity
    Drug selective if only affects one type of cell or tissue
  9. Agonist
    • Bind to receptor and initiate change
    • Affinity
    • Efficacy
  10. Antagonist
    • Bind to receptor but doesn’t cause changes
    • Affinity
  11. If you have too much painkiller what an agonist/ antagonist will do? What if it is mixed?
  12. Antagonists Competitive
    • Vying for the same receptor as agonist
    • Concentration related
  13. Antagonists Noncompetitive
    • Strong bonds formed than agonist and receptor
    • Not concentration driven
    • Irreversible
  14. Mixed agonist-antagonist
    • Stimulate certain receptor subtype while simultaneously blocking the effects of endogenous substances on other receptor subtypes
    • High affinity

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