Ch 15 2 Pharm

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Author:
jld15
ID:
303868
Filename:
Ch 15 2 Pharm
Updated:
2015-06-09 17:05:55
Tags:
15 Pharm
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Description:
Ch 15 2 Pharm
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  1. COX-2 Inhibitors
    • Better tolerated
    • Inhibit synthesis of inflammatory prostaglandins
    • Spare the synthesis of beneficial prostaglandins
    • ---- less likely GI bleed
    • Don’t inhibit platelet function
    • ---- Cox 1 does
  2. COX 2 Inhibitors adverse effect
    • Risk of heart attack and stroke
    • ---- prevents vasodilation
    • ---- don’t inhibit clot formation
    • Many removed from market or strong warnings against use
  3. Acetaminophen
    • Affect fever, mild to moderate pain but not inflammation or vascular conditions
    • Not anticoagulants
    • Not a GI irritant
    • Can be toxic to the liver
    • Large amounts of NAPQI conversion to mercapturic acid results in damage
  4. Therapist Considerations
    • Few effects that interfere with therapy
    • Not as effective for moderate – to – severe pain, or progressive inflammation

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