Ch 16 2 Pharm

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Author:
jld15
ID:
303912
Filename:
Ch 16 2 Pharm
Updated:
2015-06-10 12:35:25
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16 Pharm
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Ch 16 2 Pharm
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  1. Azathioprine (Imuran) Mechanism of Action
    • Impair DNA/RNA precursors
    • Inhibit lymphocyte proliferation
    • ----Impairing immune response from cells
    • --------Slowing down the autoimmune response of RA
  2. Etanercept (Enbrel)
    • TNF (tumor necrosis factor inhibitors)
    • TNF alpha is a protein (cytokine) key chemical mediator that promotes inflammation and joint erosion
    • Delays progression of disease
    • Given by SQ injections
  3. Etanercept (Enbrel) Adverse effects
    Increase risk of infections
  4. Gold Therapy
    • Can arrest progression not reverse damage
    • Used for those who fail to respond to other DMARDs
  5. Gold therapy Mechanism of Action
    • Inhibit growth and function of T cells and mononuclear phagocytes
    • Drug accumulates in lysosomes of macrophages and other synovial cells suppressing cellular immune function
    • Decreased lysosomal enzyme release
    • Decreased prostaglandin E2 production
  6. Gold Therapy Adverse effects
    • GI
    • Integumentary rash/ itching
  7. Lefluomide (Arava)
    • Gold therapy
    • decreases pain and inflammation
    • Slows formation of bone erosions
  8. Lefluomide (Arava) Mechanism of Action
    • Block enzyme responsible for synthesis of RNA in lymphocytes
    • Reducing inflammation
  9. Lefluomide (Arava) Side effects
    • GI distress
    • Integumentary
    • Hair loss
    • Affects liver
  10. Methotrexate(Folex, Pheumatrex)
    • Antimetabolite
    • Very effective
    • Impairs DNA/RNA synthesis
  11. Adverse effects Methotrexate
    • Most people stop drug bc of adverse side effects
    • Toxic
    • GI
    • ---- LOA
    • ---- Nausea
    • ---- Hemmorahe
    • long term care
    • ----Pulmonary problems
    • ----Hemolytic disorder
    • ----Liver function
    • ----Hair loss
  12. Combination Therapy DMARDs
    • Methotrexate + another DMARD
    • ----Hydroxychloroquine and sulfasalazine
    • ----TNF alpha inhibitor and IL-1 inhibitor
  13. Combination Therapy DMARDs Advantages
    Attack disease process from several pharmacologic vantage points
  14. Combination Therapy DMARDs Drawbacks
    • Increased toxicity
    • ----Normally have high toxicity so when add them together add the toxicities
    • Drug interaction

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