Ch 18 2 Pharm

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Author:
jld15
ID:
303922
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Ch 18 2 Pharm
Updated:
2015-06-10 16:53:16
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18 Pharm
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Ch 18 2 Pharm
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  1. Four sites of synaptic transmission of autonomic neurotransmitters
    • 1. The synapse between the preganglionic and postganglionic neurons in the sympathetic system
    • ----Cholinergic: Ach
    • 2. The same in the parasympathetic system
    • ----Cholinergic: Ach
    • 3. Synapse between the sympathetic postganglionic neuron and the effector cell
    • ----Adrenergic: NE
    • ----Some have Ach (Sweat glands, certain blood vessels of face, neck and LE_
    • 4. The same in the parasympathetic system
    • ----Cholinergic: Ach
    • All preganglionic neurons and parasymp post are cholinergic with Ach
  2. Neurotransmitters autonomic system with receptors
    • Cholinergic
    • ----Ach
    • Adrenergic
    • ----NE
  3. Acetylcholine
    • Transmitter at the preganglionic-postganglionic synapses in both systems
    • Transmitter at the parasympathetic-effector cell synapse
    • Therefore cholinergic in nature
  4. Norepinephrine
    • Transmitter at the sympathetic-effector cell synapse
    • Therefore adrenergic in nature
  5. Cholinergic receptors
    • Nicotinic
    • Muscarinic
  6. Nicotinic
    • Mediates transmission to post ganglionic receptor
    • Located at junction btwn preganglionic and postganglionic neurons of symp and parasymp
    • ----Therefore any drug that affects these receptors affects both divisions of ANS
    • Type 1 (NN): located in ANS
    • Type 2: (NM): located in skeletal neuromuscular junction
  7. Muscarinic
    • Located at al synapses btwn cholinergic postganglionic neurons and terminal effector cell
    • ----Visceral and smooth muscle
    • ----Cardiac muscle
    • ----Exocrine glands
    • ----Sweat glands
  8. Adrenergic receptors
    • Alpha
    • Beta
  9. Alpha-1
    • Vascular smooth m.
    • Intestinal smooth m.
    • Urinary sphincter
  10. Alpha-2
    • Modulate release of NE from presynaptic terminal
    • ---- acts as negative feedback limiting further release from presynaptic terminal
    • CNS inhibitory synapses
    • GI tract Pancreatic cells
    • ----Decrease motility
    • ----Decrease insulin secretion
  11. Beta-1
    • Cardiac muscle
    • ----Beta blockers
    • Kidney
    • Fat cells
  12. Beta-2
    • Bronchiole smooth m.
    • Some arterioles
    • GI smooth m
    • Uterus
    • GB
  13. Pharmacologic Significance of Autonomic Receptors
    • Drug specific receptors
    • Affect receptors of that subtype in all organs
    • Fairly selective
    • May have minimal effects on other body systems

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