Ch 20 3 Pharm

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Author:
jld15
ID:
303928
Filename:
Ch 20 3 Pharm
Updated:
2015-06-10 18:20:07
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20 Pharm
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Ch 20 3 Pharm
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  1. Dobutrex (dobutamine)
    • Short term management of decomposition
    • Intravenous pump infusion to keep plasma levels stable
  2. Intropin (dopamine)
    • Low doses
    • ----Peripheral vasodilation in the viscera and kidneys by stimulating dopamine receptors
    • --------Helps sustain kidney function in those with heart failure (bc increase cardiac input and renal blood flow)
    • Higher doses
    • ----Peripheral vasoconstriction by directly stimulating vascular aloha 1 receptors and increasing release of NE
    • --------Helps sustain BP in hypotension
  3. Beta 1 Selective Agonists adverse effects
    • Chest pain
    • Arrhythmias
    • SOB/ dyspnea
  4. Beta-2 Selective Agonists
    • Treat bronchospasms
    • Selective bronchodilators
    • Reproductive
  5. Beta 2 selective agonists Adverse effects
    • Nervousness, restlessness, trembling
    • Occasionally increased HR and BP
  6. Drugs with Mixed Agonist Activity drugs
    • Amphetamines
    • Ephedrine (generic)
    • Epinephrine (adrenalin, Bronkaid Mist, Primatene Mist)
    • Norepinephrine (Levophed)
    • Phenylpropanolamine (Acutrim, Dexatrim, Propagest)
  7. Amphetamines
    • Increase NE release
    • Decrease NE reuptake
    • Break down at adrengeic synapses
    • Increasing activity at NE sensitive receptors
  8. Ephedrine (generic)
    • Increase release of NE from presynaptic storage sites
    • Directly stimulates A1, A2, B1, or indirectly by increasing release of NE
  9. Epinephrine (adrenalin, Bronkaid Mist, Primatene Mist)
    • Directly stimulate all 4 receptors
    • Asthma
    • Bleeding during minor surgical procedures
    • Anesthetic in dental procedures
    • Cardiac arrest
    • Anaphylactic shock
  10. Norepinephrine (Levophed)
    • Bind to A1, A2, B1
    • Intravenous to treat hypotension during shock or general anesthesia
  11. Phenylpropanolamine (Acutrim, Dexatrim, Propagest)
    • Directly stimulate alpha and beta receptors
    • Or indirectly by: Increase release of presynaptic NE
    • Treatment
    • ----Nasal decongestion
    • ----Appetite suppressant
    • ----Urinary incontinence
  12. Adverse effects Mixed agonist-antagonists
    • Nervousness, restlessness, anxiety
    • Cardiac effects
    • ----Hypertension
    • ----Arrhythmias
    • ----MI
    • Respiratory effects
    • ----Bronchial irritation
  13. Alpha Antagonist
    • Used primarily to reduce peripheral vascular tone
    • Used for peripheral vasodilation
    • ----Hypertension
    • Increase peripheral vasoconstriction by excessive adrenergic influxes
    • ----Decrease BP though peripheral resistance
    • Vasodilation in vascular insufficiency
    • ----PVD
    • Tend to be alpha-1 selective
  14. Prazosin (minipress)
    • Alpha antagonist
    • Produces vasodilation in both arteries and veins
    • ----Long term management of htn

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