Ch 20 4 Pharm

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Author:
jld15
ID:
303929
Filename:
Ch 20 4 Pharm
Updated:
2015-06-10 18:20:48
Tags:
20 Pharm
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Description:
Ch 20 4 Pharm
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  1. Adverse effects alpha antagonists
    • Reflex tachycardia
    • ----Block A1 receptors, decrease BP by decreasing peripheral vascular resistance
    • Orthostatic hypotension
    • ----Decreased vascular tone
  2. Beta Antagonists
    • Used for their effect on beta-1 receptors
    • Decreases cardiac contractility and rate of contraction
  3. Beta Antagonists drugs
    • Acebutolol (Sectral)
    • Atenolol (Tenormin)
    • Metroprolol (Lopressor, Toprol-XL)
    • Nadolol (Corgard)
    • Pindolol
    • Propranolol (Inderal)
    • Acebutolol (Sectral)
    • Cardioselective beta blocker
    • binds to B1 at low doses
    • binds to both types as dose increases
    • mild to moderate intrinsic sympathomimetic activity
    • only blocks effects of endogenous catecholamines but also stimulates the receptor to some extent
    • Treatment
    • ----Htn
    • ----Prevent/treatment arrhythmias
  4. Atenolol (Tenormin)
    • Beta 1 selective but less selective at higher doses
    • Oral for long term treatment of htn or chronic stable angina
    • Administered after MI to prevent reinfarction and promote recovery of myocardium
  5. Metroprolol (Lopressor, Toprol-XL)
    • Cardioselective beta blocker
    • Treatment
    • ----Htn
    • ----Prevent angina
    • ----Prevent MI
  6. Nadolol (Corgard)
    • Non selective beta blocker
    • Treatment
    • ----Htn
    • ----Prevent angina
  7. Pindolol
    • Nonselective beta blocker that exhibits highest level of intrinsic sympathomimetic activity of all beta blockers
    • Treatment
    • ----Htn: Long term
    • ----Prevent angina
  8. Propranolol (Inderal)
    • Nonselective beta blocker
    • Treatment
    • ----Htn
    • ----Angina
    • ----Arrhythmias
    • ----Prevent MI
    • ----HA
    • ----Pheochromocytoma
  9. Beta Antagonists adverse effects
    • Beta 2
    • ----Bronchoconstriction (increase airway resistance)
    • Selective/nonselective beta blockers
    • ----Excessive depression of cardiac function
    • --------Cardiac failure
    • Beta blockers
    • ----Orthostatic hypotension
    • ----Depression
    • ----Lethargy
    • ----Sleep disorders

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