Inflammation 1

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Author:
jld15
ID:
303994
Filename:
Inflammation 1
Updated:
2015-06-13 16:48:57
Tags:
Inflammation
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Description:
Inflammation 1
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  1. Mechanisms of Cell Injury
    • Ischemia
    • Infectious agents
    • Immune reactions
    • Genetic factors
    • Nutritional factors
    • Physical factors/mechanical
    • Chemical factors
    • Free radical formation
  2. Cell injury Reversible
    If stimulus removed cell can go back to normal
  3. Cellular adaptation reversible cell injury
    • Atrophy
    • Hypertrophy
    • Hyperplasia
    • Metaplasia
    • Dysplasia
  4. Irreversible cell injury
    Once stimulus removed cell still damaged
  5. Irrversaible cell injury categories
    • Cell death
    • Necrosis
    • ----Formation of dead tissue from active degradation of those dead cells (break down)
    • ----Can release markers into blood stream and can be measured
    • Scar formation
  6. Factors that Affect Healing
    • General health
    • Comorbidities
    • Substance use
    • Nutritional status
    • Type of tissue
    • Presence of infection
    • Vascular supply
    • Immobilization
  7. Phases of healing
    • Hemostasis
    • Inflammation
    • Proliferation
    • Remodeling
  8. Hemostasis
    • Initial Clotting
    • Release of chemicals to begin inflammation process
    • Initially get vasoconstriction to area
    • Not clear cut change btwn hemostasis and inflammation
  9. Key components of inflammation
    • Blood vessels
    • Circulating blood cells
    • Connective or interstitial tissue cells
    • Chemical mediators
    • ----Call all the cells over
    • Extracellular matrix components
    • ----Collagen
    • Leukocyte
    • ----Prevent infection
    • Macrophages
    • ----Clean up
  10. Cardinal Signs of Inflammation
    • Erythema
    • Edema
    • Heat
    • Pain
    • Decreased function
  11. Vascular alterations from inflammation
    • Transudation
    • ----Fluid leaking though membrane
    • Exudates (high protein drainage)
  12. Exudates
    • Hemorrhagic
    • ----Bleeding
    • Serosanguinous
    • ----Pink (Little blood)
    • ----Expected 48-72 hrs after injury
    • Serous
    • ----Clear
    • Purulent
    • ----Pus
    • Catarrhal
    • ----Thin and clear
    • ----When you blow your nose
    • Fibrinous
    • ----Stringy, on back of throat in strep throat
  13. Chemical Mediators
    • Histamine
    • Platelet activating factor
    • Arachidonic acid derivates
    • Cytokines
    • Blood coagulation system
    • Fibrinolytic system
  14. Histamine
    • Vasodialates by increasing permeability
    • Makes it easier for chemicals from blood to get to tissue

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