Inflammation 2

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Author:
jld15
ID:
303995
Filename:
Inflammation 2
Updated:
2015-06-13 16:50:38
Tags:
Inflammation
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Description:
Inflammation 2
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  1. Platelet activating factor
    Starts clotting cascade
  2. Arachidonic acid derivatives
    Mediate fever and pain
  3. Cytokines
    • Produced by leukocytes
    • Messenger btwn cells
    • Cause fever, hypotension, release of C-reactive protein (lab value to measure inflammation)
  4. Blood coagulation system/ fibrinolytic system
    • Works with fibrinolytic system as checks and balances to preserve the function of the blood vessel
    • Prevent changes
  5. Phagocytes
    • (clean things up)
    • Neutrophils
    • Monocytes
    • Macrophages
  6. Neutrophils
    • Dominate acute phase
    • First on scene (within 24 hrs)
    • Release chemical that binds to Fe
    • ----Bc microorganisms that cause infection fuel on Fe, so eat iron so the infection cant spread
  7. Monocytes/ macrophages
    Clean up debris
  8. Proliferation and Migration
    • Granulation tissue
    • Development of new blood vessels (Angiogenesis)
    • Synthesis of extracellular matrix
    • ----Fibronectin
    • ----Proteoglycans & Elastin
    • ----Collagen
  9. Remodeling and Maturation
    • Scar tissue reduced and remodeled
    • Decreased concentration of blood vessels
    • ----That’s why it isn’t as red
    • Contracture
    • ----If severe bc tissue may be shorter than original
  10. Regeneration vs Repair
    • Depends on cell type
    • ----Labile
    • --------Continuously divides and replaces (Ex: skin, bone marrow)
    • ----Stable
    • --------Can be induced to divide (if injury) (Ex: SM, liver, kidney)
    • ----Permanent
    • --------No division (Cells die, cant be replaced, Ex: cardiac)
  11. Muscle Contusion vs strain vs sprain
    • Contusion: bruise
    • Strain: muscle
    • Sprain: ligament
    • Transection
    • ----Tissue caught
    • ----Scaring
  12. Bone Fracture healing
    • Inflammatory
    • ----fx hematoma
    • Repair
    • ----Formation of soft callus 2 w
    • ----Hard callus 6 w
    • Remodel
    • ----That’s why you need weight bearing
    • ----Excess callus absorbed
  13. Tendons/ligaments Healing
    • Inflammatory
    • ----CT brought to area
    • Proliferation
    • ----Frame work
    • Remodeling
    • ----With correct stresses
    • Nerve healing
    • ----Axonal sprouts with 24hrs but usually need surgery
  14. Effects of Immobilization
    • Muscle
    • ----Atrophy, weakness, contracture
    • Bone
    • ----Osteopenia
    • Lung
    • ----Decreased airway clearance
    • ----Increased chance of pneumonia
    • Blood
    • ----Decreased hematocrit and plasma volume
    • --------Bc less fluid in body
    • Heart
    • ----Decreased contraction strength (Doesn’t have to work as hard laying down)
    • ----Decreased endurance
    • ----Increased work of heart with submax load

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