Chenn Chenn Acquired Immunideficiency Virus
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How is HIV diagnosed
- HIV-1: enzyme-linked immunosorbent assay (ELISA) to detect antibodies to HIV-1.
- Nonreactive results considered HIV-negative
- Confirmatory test Western blot or, less commonly, an immunofluorescence assay (IFA)).
Treatment for HIV
- highly active antiretroviral therapy, or HAART
- nucleoside analogue reverse transcriptase inhibitors (NARTIs or NRTIs) plus either a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor (NNRTI)
When to commence HIV treatment
- Start before the patient's CD4 count less 200,
- National guidelines falls below 350;
To successfully reproduce itself, HIV
Convert its RNA to DNA, which is then imported into the host cell's nucleus and inserted into the host genome through the action of HIV integrase.
HIV infection has basically four stages:
- incubation period, asymptomatic and usually lasts between two and four weeks.
- acute infection: 28 days symptoms fever, lymphadenopathy, pharyngitis, rash, myalgia, malaise, mouth and esophageal sores.
- latency stage: few or no symptoms from two weeks to twenty years and beyond
- AIDS: symptoms of various opportunistic infections.
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