Bacteriostatic drugs: Inhibit growth of bacteria
Bactericidal drugs: Kill bacteria
What are the indications for penicillin use? What are the indications for amoxicillin and ampicillin? Contraindications? Therapeutic effects? Side Effects? Adverse Reactions?
? Introduced to kill Staphyloccus
? Inhibit bacterial cell wall synthesis
penicillin G, penicillin V, procaine penicillin G, benzathine penicillin G
Treatment of a wide variety of infections including: Pneumococcal pneumonia, Streptococcal pharyngitis, Syphilis, Gonorrhea strains. Treatment of enterococcal infections (requires the addition of an aminoglycoside). Prevention of rheumatic fever. Should not be used as a single agent to treat anthrax.
Bind to bacterial cell wall, resulting in cell death.
Therapeutic Effects: Bactericidal action against susceptible bacteria. Spectrum: Active against: Most gram-positive organisms, including many streptococci
(Streptococcus pneumoniae, group A beta-hemolytic streptococci), staphylococci (nonpenicillinase-producing strains) and Bacillus anthracis, Some gramnegative organisms, such as Neisseria meningitides and Neisseria gonorrhoeae (only penicillin susceptible strains), Some anaerobic bacteria and spirochetes including Borellia burgdorferi.
Contraindicated in: Previous hypersensitivity to penicillins (cross-sensitivity may exist with cephalosporins and other beta-lactams); Hypersensitivity to procaine or benzathine (procaine and benzathine preparations only); Some products may contain tartrazine and should be avoided in patients with known hypersensitivity.
Adverse Reactions/Side Effects
CNS: SEIZURES. GI: PSEUDOMEMBRANOUS COLITIS, diarrhea, epigastric distress, nausea, vomiting. GU: interstitial nephritis. Derm: rash, urticaria. Hemat: eosinophilia, hemolytic anemia, leukopenia. Local: pain at IM site, phlebitis at IV site. Misc: allergic reactions including ANAPHYLAXIS and SERUM SICKNESS, superinfection.
Treatment of: Skin and skin structure infections, Otitis media, Sinusitis, Respiratory infections, Genitourinary infections. Endocarditis prophylaxis. Postexposure inhalational anthrax prophylaxis. Management of ulcer disease due to Helicobacter pylori. Unlabeled Use:Lyme disease in children _8 yr.
Binds to bacterial cell wall, causing cell death.
Therapeutic Effects: Bactericidal action; spectrum is broader than penicillins. Spectrum: Active against: Streptococci, Pneumococci, Enterococci, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Neisseria meningitidis, N. gonorrhoeae, Shigella, Chlamydia trachomatis, Salmonella, Borrelia burgdorferi, H. pylori.
Contraindicated in: Hypersensitivity to penicillins (cross-sensitivity exists to cephalosporins and other beta-lactams).