HIV

Card Set Information

Author:
jcu1
ID:
304241
Filename:
HIV
Updated:
2015-06-20 15:18:57
Tags:
NAPLEX
Folders:

Description:
NAPLEX
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user jcu1 on FreezingBlue Flashcards. What would you like to do?


  1. Abacavir class and brand name
    NRTI (Ziagen)
  2. Didanosine class and brand
    NRTI (Videx EC)
  3. Emtricitabine class and brand
    NRTI (Emtriva)
  4. Lamuvudine class and brand
    NRTI (Epivir)
  5. Stavudin class and brand
    NRTI (Zerit)
  6. Tenofovir class and brand
    NRTI (Viread)
  7. Zidovudine brand and class
    NRTI (Retrovir)
  8. Combivir
    zidovudine/lamivudine
  9. Epzicom
    Abacavir/Lamivudine
  10. Trizivir
    Abacavir/Lamivudine/Zidovudine
  11. Truvada
    Emtricitabine/Tenofovir
  12. NRTI elimination and exceptions
    mostly renal

    • abacavir: metabolized by alcohol dehydrogenase
    • zidovudine: glucuronidation
  13. how to take NRTIs
    with food

    except didanosine - empty stomach
  14. NRTI BBW
    • lactic acidosis
    • hepatomegaly with steatosis (especially with stavudine, didanosine, and zidovudine)
  15. AE specific to stavudine and didanosine
    • peripheral neuropathy
    • pancreatitis
  16. AE specific to tenofovir
    nephrotoxicity
  17. AE specific to zidovudien
    BMS
  18. AE specific to abacavir
    hypersensitivity rxn (do not rechallenge if this happens)

    HLA-B*5701 screening before starting tx
  19. NRTI drug interactions
    no CYP-P450 interactions

    • didanosine, stavudine: additive peripheral neuropathy (vincristing, cisplatin, isoniazide)
    • abacair: alcohol dehyrogenase (alcohol inc AUC)
    • zidovudine: additive BMS (ganciclovir)
  20. NRTI MOA
    inhibit reverse transcriptase by binding to viral RNA
  21. NNRTI MOA
    Non-nucloeotide Reverse Transciptase Inhibitor

    inhibit reverse transcriptase by binding directly to it
  22. Delavirdine class and brand
    NNRTI (Rescriptor)
  23. Efavirenz class and brand
    NNRTI (Sustiva)
  24. Nevirapine class and brand
    NNRTI (Virammune)
  25. Etravirine class and brand
    NNRTI (Intelence
  26. Rilpivirine class and brand
    NNRTI (Edurant)
  27. NNRTI metabolism
    • no renal dose adjustments
    • many CYP interactions
  28. NNRTI resitance
    very susceptible to resistance (single mutation gives resistance to whole class)
  29. NNRTI side effects
    • hepatotoxicity
    • rash (SJS/TEN)
  30. AE specific to efavirenz
    • CNS AEs (vivid dreams, dizziness, confusion)
    • -- use in caution with people with preexisting psych issues or previous substance abuse

    more dyslipidemia than other NNRTIs
  31. preferred NNRTI and how to take
    • efavirenz
    • at bedtime
  32. atazanavir class and brand
    PI (Reyataz)
  33. darunavir class and brand
    PI (Prezista)
  34. Protease inhibitor MOA
    inhibit HIV-1 protease, so that enzyme can't cleave the protein that produces mature viruses
  35. PI side effects
    • hyperglycemia/insulin resistance/DM
    • lipoatrophy/fat maldistribution
    • hyperlipidemia
    • hepatitis
    • immune reconstitution syndrome
    • diarrhea
  36. preferred NNRTI in pregnancy
    Nevirapine
  37. preferred PI in pregnancy
    • atazanavir
    • lopinavir + ritonavir
  38. AE specific to atanavir
    • hyperbilirubinemia and jaundice
    • PR interval prolongation
  39. Preferred NRTIs
    • emtricitabine
    • tenofovir
    • abacavir
    • lamivudine
  40. preferred NNRTIs
    efavirenz
  41. preferred PIs
    • atazanavir
    • darunavir
    • lopinavir/ritonavir
    • ritonavir
  42. preferred INSTI
    raltegravir
  43. preferred NNRTI-based regimen
    efavirenz + tenofovir/emtricitabine
  44. preffered PI-based regimen
    • atazanavir/ritonavir + tenofovir/emtricitabine
    • darunavir/ritonavie + tenofovir/emtricitabine
  45. preferred INSTI-based regimen
    • raltegravir + tenofoivir/emtricitabine
    • elvitegravir/cobicistat/tenofovir/emtricitabine (Stribild)
    • dolutegravir + abacavir/lamivudine or tenofovir/emtricitabine
  46. preferred PI-based regimen in pregnancy
    • lopinavir/ritonavir (BID dosing) + zidovudine/lamivudine
    • atazanair/ritonavir + zidovudine/lamivudine
  47. preferred NNRTI-based regimen in pregnancy
    nevirapine + zidovudine/lamivudine
  48. Kaletra
    lopinavir + ritonavir
  49. Atripla generic
    efavirenz + emtircitabine/tenofovir
  50. Complera generic
    rilpivirine + emtircitabine/tenofovir
  51. Stribild generic
    elvitegravir/cobicistat + emtricitabine/tenofovir
  52. NNRTI-based nonoccupational postexposure prophylaxis (nPEP) recommendation
    • efavirenz +
    • (lamivudine or emtricitabine) +
    • (zidocudine or tenofovir)

    x 28 days
  53. PI-based nonoccupational postexposure prophylaxis (nPEP) recommendation
    • lopinavir/ritonavir +
    • (lamivudine or emtricitabine) +
    • zidovdine

    x 28 days
  54. occupational postexposure prophylaxis (PEP)
    • 3 drug regimen:
    • raltegravir + tenofovir/emtricitibine (Truvada) x 4 weeks

What would you like to do?

Home > Flashcards > Print Preview