infectious disease - disease and 1st line therapy

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Author:
coal
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304783
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infectious disease - disease and 1st line therapy
Updated:
2015-07-04 17:13:04
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infectious disease 1st line therapy
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infectious disease - disease and 1st line therapy
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infectious disease - disease and 1st line therapy
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  1. first line for acute otitis media
    • amoxicillin 80-90 mg/kg/day in 2 divided doses
    • or
    • augmentin 90 mg/kg/day in 2 divided doses
  2. treatment of acute otitis media and a pcn allergy
    cefdinir 14 mg/kg/day in 1 or 2 doses
  3. 3 common bug of community acquired pneumonia
    • streptococcus pneumoniae
    • haemophilus influenzae
    • moraxella catarrhalis
  4. empiric outpatient treatment of CAP
    • macrolide (azithromycin, clarithromycin, erythromycin)
    • or 
    • doxycycline
  5. empiric inpatient (non-icu) treatment of CAP
    • beta-lactam
    • plus
    • macrolide
  6. empiric inpatient (ICU) treatment of CAP
    • IV therapy preferred
    • beta-lactam (ceftriaxone, cefotaxime, ampicillin/sulbactam)
    • plus
    • azithromycin or a FQ
  7. oral antibiotic therapy for CAP
    • cephalosporins
    •    cefpodoxime
    •    cefuroxime (ceftin)
    •    cefdinir
    • macrolides
    •    azithromycin (zithromax)
    •    clarithromycin (biaxin)
    •    erythromycin 
    • FQ's
    •    levofloxacin (levaquin)
    •    moxifloxacin (avelox)
    •    gemifloxacin (factive)
    • tetracyclines
    •    doxycycline (vibramycin)
    • penicillins
    •    amoxicillin (amoxil)
    •    augmentin
  8. regimen of choice for treating possible drug-resistant Strep. pneumoniae
    beta-lactam + doxycycline
  9. aminoglycoside renal dosing intervals
    • CrCl > 60 = q8h
    • 40-60 = q12h
    • 20-40 = q24h
  10. trough and peak levels of aminoglycosides
    • tobramycin & gentamycin; P - 5-10, T <2
    • amikacin; P - 20-30, T < 5
  11. FQ MOA
    inhibits topoisomerase, blocking DNA gyrase
  12. pyrazinamide CI
    • acute gout
    • severe hepatic damage
  13. treatment of choice for patients at risk of drug resistant S. pneumonia CAP
    • respiratory fluoroquinolones
    • at risk: age, co-morbidities
  14. fluconazole PO:IV ration
    1:1
  15. metronidazole PO:IV ratio
    1:1
  16. bactrim PO:IV ratio
    1:1
  17. typical drugs of choice for prophylactic peri-operative procedures
    1st and 2nd gen cephalosporins
  18. concentration dependent killing antibiotics
    • aminoglycosides
    • FQ's
    • daptomycin
    • colistin
  19. time dependent killing antibiotics
    beta-lactams
  20. AUC:MIC dependent killing antibotics
    • vancomycin
    • macrolides
    • tetracyclines

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