endocrine system

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Author:
BodeS
ID:
305060
Filename:
endocrine system
Updated:
2015-07-14 18:53:39
Tags:
pharmacology
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Description:
drugs, hormones, disorders, diseases
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  1. thiomides
    • trade name: Propylthioracil 
    • Tapazole
    • ID: antithyroid drug
    • treat: hyperthyroidism
    • Grave's disease
    • target: iodine 
    • action: block synthesis of T3, T4
    • location: thyroid
    • risk: hepatotoxicity- blood disorders
    • nephrotoxicty-inhibits erthryopioetin
  2. calcitonin
    • official name: Calcitonin
    • ID: thyroid hormone
    • treat: osteoporosis
    • hyperparathyroidism
    • target: Ca++
    • action: promote Ca++ absorption into bone
    • location: thyroid
  3. fludrocortisone
    • trade name: Florinef
    • ID: adrenal cortex hormone
    • mineral corticoid
    • corticosteroid
    • treat: adrenocortical insufficiency
    • salt-losing adrenogenital syndrome
    • Addison's disease
    • target: Aldosterone
    • action: mineral corticoid effects
    • glucocorticoid effects
    • reabsorb Na+ and H2O
    • secret K+
    • contraindicated: high BP
    • risk: hypertension
    • electrolyte imbalance
  4. Anabolic steroid hormones
    • ID: schedule III drug
    • androgen
    • fxn: sport performance
    • risk: acne
    • hypertension
    • testicular atrophy
    • increase LDL cholesterol
  5. Adrenal Medulla Hormones
    • ID: cathecholamines
    • drugs: Adrenaline
    • Levophed
    • Albuterol [Proventil]
    • Sudaphed [Pseudoephdrine]
    • action: affect heart
    • blood vessels
    • bronchi
    • nasal congestion
  6. Adrenal Cortex Hormones
    • ID: glucocorticoids
    • mineral corticoids
    • gonadal hormones
    • fxn: sugar
    • salt
    • testosterone/estrogen
  7. zona fasciculata
    • ID: glucocorticoids
    • sugar
    • middle layer 
    • adrenal cortex hormone
    • fxn: adaptation to stress 
    • target: Cortisol
    • action: gluconeogenesis
    • location: made in kidney
    • gluconeogensis in liver
    • risk: hyperglycemia
    • contraindicated: diabetes
    • drugs: Synthroid
  8. zona glomerulosa
    • ID: mineral corticoid
    • salt
    • outer layer
    • adrenal cortex hormone
    • fxn: reabsorb Na+, H2O
    • secrete K+
    • increase BP
    • target: Aldosterone
    • drugs: Florinef
  9. zona reticularis
    • ID: gonadal hormones
    • sex
    • inner layer
    • adrenal cortex hormone
    • fxn: anabolic steroid
    • secondary sex characteristics
    • target: androgen
    • drugs: progestin
    • testosterone
  10. albuterol
    • trade name: Proventil 
    • ID: adrenergic
    • bronchodilator
    • vasodilator
    • adrenal medulla hormone
    • cathecholemine 
    • route: PO [inhaler]
    • treat: asthma
    • target: beta2 receptors
    • action: beta2-adrenergic agonist
    • decrease smooth muscle contraction in airways
    • promotes smooth muscle relaxation in airways
    • glucogenolysis
    • location: lungs
    • liver
    • risk: paradoxical bronchospasm
    • contraindicated: non-selective beta-blockers
    • risk: children-hyperactivity
    • cross-sensitivity to hypertension
    • diabetes
    • glaucoma
  11. Prednisone
    • official name: corticosteroid
    • cortisone
    • hyrdrocortisone
    • ID: glucocorticoid hormone
    • adrenal cortex hormone
    • antiasthmatics
    • anti-inflammatory
    • antiallergenic
    • route: PO [topical, parenteral]
    • treat: asthma
    • arthritis
    • target: Cortisol 
    • action: suppress tissue inflammation 
    • increase Cortisol production
    • gluconeogensis
    • location: adrenal cortex
    • liver
    • tissue
    • contraindicated: uncontrolled diabetes
    • osteoporisis
    • risk: long term adverse effect-
    • increased wound healing time
    • masks s/s of infection
    • promotes Ca++ loss
    • PUD
    • Hyperglycemia
  12. cortisol
    ID
    fxn
    location
    • ID: glucocorticoid
    • fxn: increase blood sugar
    • gluconeogenesis
    • suppress autoimmune response
    • decrease bone formation
    • risk: hyperglycemia
    • weight gain
    • bone loss
  13. levothyroxin
    • brand name: Synthroid
    • ID: thyroid hormone
    • thyroid preparation
    • thyroxine
    • route: PO, IV, IM
    • treat: hypothyroidism
    • target: T4
    • action: partially metabolize T4 into T3
    • restore endogenous thyroid hormone balance
    • location: thyroid
    • contraindication: hyperthyroidism
    • risk: cardiac symptoms
    • tachycardia
    • short half-life
    • life-long therapy
  14. catecholamines
    • location: adrenal medulla
    • ID: hormones
    • drugs: Adrenaline [epinephrine]
    • Levophed [noriepinephrine]
    • treat: cardiac arrest
    • allergic reaction
    • hypotension/shock
  15. non-catecholamines
    • location: adrenal medula 
    • ID: hormones
    • drugs: Proventil [albuterol]
    • Pseudoephedrine [sudaphed]
    • treat: asthma
    • nasal congestion
  16. Progestin
    • trade name: Progestin
    • ID: oral contraceptive
    • estrogen
    • treat: contraception 
    • reduce risk of cancer
    • hormone balance
    • target: FSH
    • LH
    • action: inhibit pituitary gonadotropins
    • inhibit ovulation
    • location: ovaries
    • contraindication: endometriosis  
    • risk: estrogen-cancer
  17. thyroid feedback loop
    • hypothalamus: TRH
    • anterior pituitary gland: TSH 
    • thyroid: thyroxines [T3, T4]
    • calcitonin 
  18. adrenal feedback loop
    • hypothalamus: CRH [corticoid release]
    • GnRH [gonadotropin relesase]
    • anterior pituitary gland: ACTH [adrenal corticoid]
    • adrenal cortex: cortisol
    • aldosterone
    • androgen
    • estrogen
  19. reproductive feedback loop
    • hypothalamus: GnRH
    • anterior pituitary gland: FSH [follicle stimulating]
    • LH [leuitinizing]
    • PRL [prolactin]
    • effector: adrenal cortex
    • testes 
    • breasts
    • ovaries

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