reproductive system

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  1. Estrogens 
    • conjugated equine estrogens (Premarin)
    • others: estradiol (Estrace, Bagifem), estradiol hemihydrate (Estrasorb)
  2. conjugated equine estrogens (Premarin)
    [pharmacological action]
    block bone resorption and lower LDL levels. at high levels, suppress release of FSH needed for concetion
  3. conjugated equine estrogens (Premarin)
    [therapeutic use]
    • contraception 
    • relieve postmenopausal symptoms
    • prevent postmenopausal osteoporosis 
    • tx of dysfunctional uterine bleeding 
    • tx of prostate cancer
  4. conjugated equine estrogens (Premarin)
    • -endometrial and ovarian cancers (when prolonged estrogen is the only postmenopausal therapy) 
    • -breast cancer
    • -embolic event
  5. conjugated equine estrogens (Premarin)
    • estrogen can reduce effect of warfarin 
    • -use with phenytoin can decrease effects of estrogens 
    • -steroids increase effects of estrogen 
    • -smoking increase risk for thrombophlebitis
  6. Progesterones 
    • medroxygprogesterone (Provera)
    • other: norethindrone (Micronor), megestrol acetate (Megace)
  7. medroxygprogesterone (Provera)
    [pharmacological action]
    induce favorable conditions for fetal growth and development and maintain pregg. drop in progesterone levels result in menstruation.
  8. medroxygprogesterone (Provera)
    [therapeutic use]
    • for contraception
    • -dysfunctional uterine bleeding
    • -Amenorrhea 
    • -Endometriosis 
    • -advanced cancer of breast, endometrium, and kidney
  9. medroxygprogesterone (Provera)
    • breast cancer 
    • -thromboembolic events 
    • -bleeding
    • -edema
    • -jaundice (liver toxicity) 
    • -migraine headaches
  10. Hormonal contraceptives 
  11. Hormonal contraception 
    • thromboembolic events 
    • -HTN
    • -uterine bleeding 
    • -breast cancer
  12. Androgens
    • testosterone (Androderm-50, Testopel)
    • others: methyltestosterone (Android, Testred)
  13. Androgens 
    [pharmacological action]
    • develop sex traits in men and production and maturation of sperms 
    • -increase skeletal muscle 
    • -increase synthesis of erythropoietin
  14. Androgens 
    [therapeutic use]
    tx hypogonadism in males, delayed puberty in boys, testicular failure, anemia (unresponsive to normal therapy), postmenopausal breast cancer, muscle wasting (males with AIDs)
  15. Androgens 
    • -androgenic effect 
    • -epiphyseal closure 
    • -hypercholesterolemia 
    • -polycythemia (too much RBC)
    • -edema from salt and water retention 
    • -high abuse
    • -hepatitis, jaundice 
    • -increase growth of prostate cancer
  16. 5-alpha reductase inhibitors 
    • finasteride (Proscar, Propecia)
    • others: dutasteride (Avodart)
  17. 5 Alpha reductase inhibitors 
    [pharmacological action]
    • decreases usable testosterone by inhibiting the converting enzyme, and causes reduction of prostate size and increase hair growth
    • (to treat prostate enlargement)
  18. 5 alpha reductase inhibitors 
    [therapeutic use]
    • benign prostate hyperplasia (BPH)
    • male pattern baldness
  19. finasteride (Proscar)
    • decrease libido, ejaculate volume
    • -gynecomastia 
    • -orthostatic hypotension
  20. Who should NOT handle a patient that's taking finasteride?
    the preggos
  21. patients taking finasteride should protect themselves...
    by wearing gloves
  22. People taking finasteride should not donate unless...
    unless they have stop taking the drug at least 1 month
  23. Educate patient that it will take how long for finasteride to take effect?
    at least 6 months or longer
  24. Alpha1 -adrenergic antagonists 
    • selective Alpha1 -adrenergic antagonists: tamsulosin (Flomax)
    • others:
    • selective Alpha1 -adrenergic antagonists: silodosin (Rapaflo)
    • nonselective Alpha1 -adrenergic antagonists : Alfuzonsin (Uroxatral)
    • Terazosin
    • Doxazosin (Cardura)
  25. tamsulosin (Flomax) 
    [pharmacological action]
    decrease mechanical obstruction of the urethra by relaxing smooth muscles of the bladder neck and prostate 

    nonselective agents lowers bp, for BPH and HTN
  26. tamsulosin (Flomax)
    [therapeutic uses]
    for BPH (thus increase urinary flow)
  27. tamsulosin (Flomax)
    • -Hypotension 
    • -problems with ejaculation
  28. Tamsulosin (Flomax) 
    tamsulosin should be taken 30 mins after a meal at the same time each day
  29. Phosphodiesterase type 5 (PDE5) inhibitors 
    sildenafil (Viagra) 

    others: tadalafil (Cialis), vardenafil (Levitra)
  30. sildenafil (Viagra)
    [pharmacological action]
    augments effects of nitric oxide released during sexual stimulation, results in enhancing blood flow to the corpus cavernosum and penile erection
  31. sildenafil (Viagra)
    • MI, sudden death 
    • Priapism
  32. sildenafil (Viagra)
    • -contraindicated in patients taking any meds in the nitrate family (nitroglycerin) 
    • -grapefruit juice may increase plasma conc. and possible adverse effects
Card Set:
reproductive system
2015-07-14 01:49:00
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