Osmotic laxatives (Magnesium hydroxide, magnesium citrate, polyethylene glycol, lactulose)
- MOA: Provide osmotic load to draw water into the GI lumen.
- USE : Constipation.
- Lactulose also treats hepatic encephalopathy since gut flora degrade it into metabolites (lactic acid and acetic acid) that promote nitrogen excretion as NH4+.
Diarrhea, dehydration; may be abused by bulimics