Anti-seizure medications-Pharm-Final

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  1. What is the definition of a generalized seizures?
    involves both hemispheres: loss of consciousness
  2. Define tonic-clonic seizures
    • sustained contractures, loss on consciousness
    • clonic-rapid jerking motion
    • risk for hypoxia
  3. How long do absence seizures occur for
    last less than a minute
  4. myoclonic
    rapid muscle contraction in one part of the body
  5. Atonic
    sudden loss of muscle tone
  6. Define a partial seizure
    involve 1 of the hemispheres
  7. What is a complex seizure?
    consciousness impaired
  8. What is a simple seizure?
    consciousness not impaired
  9. What is critical during a seizure?
    Safety of the patient
  10. What is the first drug of choice for Antiseizure medication?
    Phenytoin (Dilantin)
  11. What is the MoA of Phenytoin (Dilantin)?
    Na channel blocker
  12. What produces a seizure?
    Influx of sodium into cells
  13. What are contraindications of Phenytoin (Dilantin)?
    • Bradycardia, Heart Block
    • Allergy to med
    • CNS depressant
  14. What is the biggest issue for patients taking Phenytoin (Dilantin)
  15. Common ADE for Phenytoin (Dilantin)
    • Ataxia (unsteady gait)
    • lethargy
    • N/V
    • Gingival hyperplasia (gums overgrow)
  16. Serious ADE for Phenytoin (Dilantin)
    • Stevens-Johnson syndrome
    • Hepatotoxicity
  17. What are the Black Box warnings for Phenytoin (Dilantin)
    • Cat D 
    • Administer IV slowly (50mg/min)
    • Increase risk for suicide
  18. What does Phenytoin (Dilantin) need to be mixed with only?
    Normal Saline
  19. What is the benzo for antiseizures?
    Diazepam (Valium)
  20. What is the MoA of Diazepam (Valium)
    Enhances GABA
  21. What is the barbiturate for antiseizures?
    Phenobarbital (Long acting barbiturate)
  22. What is the MoA of Phenobarbital?
    CNS depressant
  23. What is Status Epilepticus?
    Recurrent Tonic-Clonic seizures
  24. What is the main cause of status epilepticus?
    Having the patient stop the medication
  25. While having status epilepticus what do you need to do?
    • Oxygen
    • IV
  26. What are 2 other benzos that the patient may take for seizures?
    • clonazepam (Klonopin)- txs absence seizures
    • Lorazepam (Ativan)-long acting
  27. How long should the seizure go until you call the PCP?
    3 minutes
Card Set:
Anti-seizure medications-Pharm-Final
2015-07-31 13:51:44
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