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With regard to immune check points all of these are inbitory except
with regards to immune check points in cancer all of these are inhibitory except?
What are the main side effects of ipilimumab?
- liver toxicity
with regards to Cetuximab use in colorectal cancer. what subset of patients will Cetuximab not work for and why?
- those without KRAS mutation.
- ( used only in Wild type KRAS )
what is the moelcular target for Cetuximab ?
What subset of people may PSA screening in prostate cancer be beneficial for
Young men aged 50-64 with a life expectancy > 10-15 years
what chemo is currently used first line in prostate cancer and has show to be beneficial if given earlier with androgen therapy?
What are the side effects of Abiraterone?
- Fluid overload
why does Abiraterone cause the side effects of mineralocorticoid excess?
Blocks CYP17 blocks conversion of progesterone to testosterone, accumulation of upstream steroids leads to increase in ACTH and
what should be given with abiraterone to prevent side effects
prednisone (low dose 10mg)
Enzalutamide is a second line anti-androgen used in prostate camcers, what makes it better than first line drugs such as Bicalutamide?
No agoinst activity even if used for a prolonged period of time
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