Oncology

Card Set Information

Author:
alig
ID:
306047
Filename:
Oncology
Updated:
2015-08-04 19:15:04
Tags:
RACP exam
Folders:
oncology medicine
Description:
Exam questions on oncology for RACP exam
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  1. With regard to immune check points all of these are inbitory except

    CTLA-4
    OX40
    CD28
    GITR
    CTLA-4
  2. with regards to immune check points in cancer all of these are inhibitory except?

    CTL-4
    PD-1
    OX40
    TIM-3
    OX40
  3. What are the main side effects of ipilimumab?
    • rash
    • diarrhoea
    • hypophysitis
    • liver toxicity
  4. with regards to Cetuximab use in colorectal cancer. what subset of patients will Cetuximab not work for and why?
    • those without KRAS mutation.
    • ( used only in Wild type KRAS )
  5. what is the moelcular target for Cetuximab ?
    EGFR
  6. What subset of people may PSA screening in prostate cancer be beneficial for
    Young men aged 50-64 with a life expectancy > 10-15 years
  7. what chemo is currently used first line in prostate cancer and has show to be beneficial if given earlier with androgen therapy?
    Docetaxel
  8. What are the side effects of Abiraterone?
    • hypoK+
    • Hypertension
    • Fluid overload
  9. why does Abiraterone cause the side effects of mineralocorticoid excess?
    Blocks CYP17 blocks conversion of progesterone to testosterone, accumulation of upstream steroids leads to increase in ACTH and
  10. what should be given with abiraterone to prevent side effects
    prednisone (low dose 10mg)
  11. Enzalutamide is a second line anti-androgen  used in prostate camcers, what makes it better than first line drugs such as Bicalutamide?
    No agoinst activity even if used for a prolonged period of time

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