Cattle- Macromineral Disorders

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  1. What are the most important macromolecules?
    calcium, magnesium, potassium, and phosphorous
  2. What are the functions of calcium? (3)
    stabilizes neuronal membranes, secretion of Ach, muscle contraction
  3. Hypocalcemia causes ________ of muscles.
  4. What are the functions of magnesium? (7)
    ATP formation/use, gene transcription, cAMP hormonal control, Ach breakdown, CNS, neuromuscular excitability
  5. What are the functions of potassium? (3)
    muscle/neuron excitability (resting cellular potential), glycogen synthesis (may lead to ischemia and muscle necrosis), acid-base balance
  6. What are the functions of phosphorous? (5)
    required for synthesis of phospholipids/proteins/nucleic acids, glucose homeostasis, production of ATP/GTP, buffer systems, matrix of bone/cartilage/extracellular tissues
  7. What are the effects on mineral concentrations with milk fever?
    hypocalcemia, normal to increased Mg, hypophosphatemia
  8. What causes milk fever?
    onset of lactation, there is a rapid decline in serum ionized calcium due to production of colostrum
  9. What are the smooth muscles effects of hypocalcemia? (7)
    dry muzzle (no sweat), cold extremities, dilated pupils, reduced anal tone, bloating, no defecation/urination, RP or uterine prolapse
  10. What are the cardiac muscle effects of hypocalcemia?
    increased HR, decreased strength/intensity of contraction, weak pulses, hypotension
  11. Describe stage 1 of milk fever. (7)
    [sometimes referred to as subclinical] standing, hyperexcitable, off feed or slug feeding, tremors, unsteady, mouth open/tongue out, gasping
  12. What is the serum calcium level in stage 1 milk fever?
  13. Describe stage 2 of milk fever. (12)
    sternally recumbant, off feed, depressed, S-curve neck, dry muzzle, cold extremities, dilated pupils, no defecation/urination, decreased heart sounds, rapid pulse, rumen stasis, RP or prolapse
  14. What is the serum calcium level in stage 2 milk fever?
    0.87-1.6 mml/L
  15. Desrcibe stage 3 milk fever. (4)
    lateral recumbancy, comatose, flaccid paralysis, bloat
  16. What is a common sequealae to stage 3 milk fever?
    aspiration pneumonia
  17. What is the serum calcium level in stage 3 milk fever?
    0.5-1 mmol/L
  18. How do you treat milk fever? (4)
    deep bedded stall, minimize stimuli, don't milk her, calcium gluconate 2g/100kg IV
  19. What should you always check for when you have diagnosed milk fever?
    coliform mastitis- may have endotoxemia or septicemia, in which case give the calcium slower or dilute it
  20. How can you check for coliform mastitis on the spot?
    if milk looks watery and yellow
  21. What are positive responses to treatment for milk fever? (8)
    eructation, urination, defecation, standing up, increased repirations, decreased HR, warmer extremities, sweating muzzle
  22. How can you prevent milk fever? (2)
    reduce potassium intake, give anionic salts to induce subclinical metabolic acidosis and urinary acid excretion
  23. What are 2 anionic salts given to cows?
    chloride, sulfate
  24. What is the Dietary cation-anion difference?
    (Na+ + K+) - (Cl- + S) = DCAD
  25. The DCAD should be maintained below _____ in the transitional period; increased ______ in the diet reduced the DCAD to increase __(2)__ absorption.
    50mEg; anionic salts; Ca2+ and Mg2+
  26. What is the best way to mointor use of anionic salts in the diet?
    monitoring urine pH
  27. What is the mean pH values of urine in pre-fresh dry cows?
  28. Anion salts work best in preventing milk fever when the _____________.
    dietary calcium is high
  29. In order for anionic salts to be successful in preventing milk fever, they must be added to the feed at least _______.
    10 days prior to calving
  30. 4 complications of hypomagnesmia.
    hyperexcitability, tetany, convulsions, death
  31. Describe grass tetany.
    pastured cows in spring and fall, high K+ and N, low Mg2+ and Na+
  32. Describe winter tetany.
    feeding Mg deficient feed to beef cows in winter, low Mg
  33. Describe milk tetany.
    stressed calves fed milk only (milk is low in Mg)
  34. Describe transport tetany.
    cattle on marginal diets transported, lack of feed/water during transportation
  35. What are predisposing factors for hypomagnesmia?(6)
    high rainfall, warmth, roughage diet, periods of fasting, high K+, high protein diet
  36. What are the clinical signs of tetany? (9)
    anorexia, hyperexcitability, pounding heart, muscle fasiculations, staggering, convulsions, head back, snapping eyelids, death
  37. What level of Mg in serum and CSF is associated with clinical signs of tetany?
  38. How can you test for tetany within 12 hours of death?
    get CSF sample or vitreous humor and test for Mg level (which is stable for 12 hours after death)
  39. What are possible differentials for cows exhibiting signs of tetany? (5)
    nervous ketosis, stage I milk fever, lead poisoning, rabies, listeriosis
  40. How do you treat tetany?
    Mg lactate/CMPK/Cal Phos IV solution, oral solutions
  41. How can you prevent hypomagnesmia?
    supplement with Mg salts; 60g/hd/day, 2oz/hd/day on silage
  42. What is kyphosis?
    S-shaped curve of neck
  43. How can the txt of ketosis lead to hypokalemia syndrome?
    multiple doses of dextrose IV and insulin causes cells to rapidly take up extracellular K+
  44. What cows are most likely to be affected by hypokalemia syndrome?
    lactating cows <60DIM, heifers/calves with significant anorexia
  45. What are the early clinical signs of hypokalemia syndrome? (5)
    rumen stasis, decreased defecation, anorexia, inability to stand for long periods, tachycardia/arrhythmia
  46. What are the later clinical signs of hypokalemia syndrome? (4)
    recumbancy, kyphosis, tachycardia/arrhythmia, fever
  47. What is the most common arrhythmia in cattle? What is it associated with?
    atrial fibrillation; hypokalemia and milk fever
  48. What are etiologies of hypokalemia syndrome? (4)
    txt with PreDef for ketosis/inflammation/udder edema, dextrose, insulin, and IV fluids for more than 2 days
  49. Hypokalemia syndrome causes weakness that may lead to... (2)
    recumbancy and myonecrosis
  50. What are differential diagnoses for animals showing signs of hypokalemia syndrome, and how can you diagnose HKS?
    hypocalcemia, botulism, tick paralysis, myelopathy, listeriosis, vertebral malformation, luxations/fractures, torticollis; lack of response to Ca2+ administration
  51. What blood values can alert you to hypokalemia syndrome? (6)
    K+<3mEq/L, elevated AST and CPK, metabolic alkalosis, hypochloremia, mild hyperglycemia
  52. How do you treat hypokalemia syndrome? (5)
    supportive care, float/ deep bedded stall, administer potassium chloride 50g/100kg, oral isotonic electrolyte fluids, K+ supplements for 5 days
  53. Do not exceed ________ rate of oral/IV administration of isotonic electrolyte fluids for a cow with HKS.
  54. Post-parturient hemoglobinuria associated hypophosphatemia occurs because...
    love P causes RBC fragility.
  55. What cows are at highest risk for hypophosphatemia? (5)
    3rd trimester of pregnancy, pregnant with twins, rickets/osteomalacia, lactation associated, [other countries] post-parturient hemoglobinuria, chronic P deficiency
  56. Most of the serum phosphorous is absorbed via the ________.
    small intestine
  57. Phosphorous deficiency is almost always due to ___________.
    low P in the ratio
  58. _________ released during __________ causes an increase in phosphorous.
    PTH (parathyroid hormone); hypocalcemia
  59. PTH (parathyroid hormone) increases...
    salivary and renal excretion of phosphorous.
  60. Low phosphorous commonly indicates low _______.
  61. In what animals does pregnancy-associated hypophosphatemia occur?
    pregnant beef cattle fed P deficient diets; late gestation demands more P
  62. How do you treat pregnancy-associated hypophosphatemia?
    feed higher energy diet (grain, which has high P), 200g NaHPO4 in water or 23g NaHPO4 in 1L of saline IV
  63. Why does lactation-associated hypophosphatemia occur?
    hypocalcemia causes release of PTH, which subsequently causes loss of P in saliva and urine
  64. How do you treat lactation-associated hypophosphatemia?
    Ca2+ txt leads to lower PTH and retention of P
  65. What is an alert downer cow?
    P<1mg/dL, low Ca2+, low Mg, low glucose
  66. If hypocalcemia txt does not restore phosphorous, the cow is probably a(n) ___________, and treat with _________.
    alert downer cow; IV phosphorous (23g in saline) or oral phosphorous (200g)
  67. In what cows does chronic P deficiency usually occur?
    grazing cattle in a tropical/temperate climate
  68. In what animals does rickets/osteomalacia causing hypophosphatemia occur?
    young animals (rickets)-improperly mineralized bone; older animals (osteomalacia)- failure of mineralization of osteoid matrix
  69. In what animals does post-parturient hypophosphatemia occur?
    <6 weeks post-calving, cows treated for ketosis, diets deficient in Se, Cu, energy, saponins in diet
Card Set:
Cattle- Macromineral Disorders
2015-09-01 19:33:50
vetmed cattle minerals

vetmed cattle diseases
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