CFM 1: Microfilaments

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Author:
jdwein39
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306939
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CFM 1: Microfilaments
Updated:
2015-08-27 15:39:27
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cfm cfm1
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  1. Profilin
    Protein that sequesters actin
  2. Myosin V
    Carries cargo; 2 myosin heads that "walk" along actin filament
  3. Myosin II
    Myosin found in muscle cells
  4. Formins/ARPs
    proteins that promote actin filament growth and polymerization
  5. Gelsolin/cofilin
    depolymerize actin filaments
  6. Tropomyosin
    binds in the helical groove of actin filament to stabilize and add strength
  7. Tropomodulin
    Protein that caps the end of the actin filament so it cannot continue to grow
  8. Vinculin
    Protein involved in binding actin filament to membrane
  9. 3 different organizational patterns of actin
    • Stress fibers: Loose antiparallel bundles
    • Gel-like network in cell cortex
    • Lamellipodia: tight parallel bundles
  10. Actin cross linking proteins
    Fimbrin, filamin, a-actinin
  11. Filamin
    actin cross-linking protein
  12. Formins
    Proteins involved in growing the actin chain at the + end
  13. ARPs
    Actin-related proteins; ARP2/3 complex initiates actin growth and forms branches of actin filament

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