1. when Cl. tetani enters the body ⇒ local infection and tissue destruction
2. multiplication of organism occurs frequently when the wound has healed. while reproducing, Cl. tetani also releases toxins that are absorbed by the bloodstream and lymphatics and directly by the peripheral motor nerves. these eventually spread in the CNS.
3. tetanospasmin has strong affinity in the CNS tissue and spinal motor ganglia