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what are 3 primary lymphoid tissues?
- Bursa of fabricius
- Bone marrow
2 types of respiratory associated lymphoid tissue?
In birds a major GIT lymphoid point is?
4 reasons for atrophy of lymphoid tissues?
- Stress and apoptosis - glucocorticoid release
- Nutrition - Zn, vit A or E/Se deficiencies
- Mycotoxins - aflatoxin, ochratoxin
What is gumboro disease?
Infectious bursal disease
IBD only seen in? what age? chronic or acute?
- 3-6 weeks old
- acute and contagious
What do we see happen to the bursa in IBD?
Edematous, hemorrhagic, atrophy etc
Lesions seen not associated with the bursa in IBD
- Vent picking
- Hemorrhage in thigh and pectoral mucles at the junction of proventriculus and gizzard
IBD high morbidity or mortality
Big impact of IBD
- gangrenous dermatitis, e. coli, inclusion body hepatitis, vaccination failures
2 strains of IBD
- Classical - atrophy and immunosuppresion
- Highly virulent - everywhere in world but Canada, hemmorrhagic necrotizing bursal lesions
IBD serotype 1 has how many subtypes, which is non pathogenic
How is IBD transmitted?
Only horizontal, very peristant in barns, very resistant to disinfection
If you have a plate of bursas how can you tell if it is IBD
- Heterogenous small bursas compared to normal
- On histo looks atrophied
Why do we need to wait till later to vaccinate birds for IBD?
Maternal antibodies protect for 3-4 weeks
Do IBD vaccines cross protect against other serotypes
Why is it so important to vaccinate parent stock when laying eggs?
- Passive immunity is passed down
- vaccinate multiple times to keep titre up
When vaccinating for IBD we prime with ____ and boost with _____
Chicken infectious anemia is what kind of virus?
- Aplastic anemia
- lymphoid depletion
- Sub Q and IM hemorrhage
What ages are susceptible to CIA
WHat is PCV with a CIA affected bird?
Is CIA virus easy to destroy
What is a complication of CIA crossing voer with other dieases?
Early infection can interfere with other vaccines
How can chicken infectious anemia make mareks and IBD more likely?
Interfere with vaccination
Describe some lesions of chicken infectious anemia
- Thymic atrophy
- Fatty yellow bone
- bursal atrophy
- Hemorrage in sub Q
Common secondary bacterial disease to CIA?
Gangrenous dermatitis (blue wing disease)
How is CIA transmitted?
Horizontally and vertically
With chicken infectious anemia do all birds that transmit the disease have to be Antibody positive?
Why do we see petechiation with Chicken anemia virus?
3 things in Chicken infectious anemia seen in clin path?
- Increased clotting time
- INcreased immature RBC
How do we control chicken infectious anemia
Humoral immunity, maternal antibodies from vaccination
Do we often have to vaccinate birds multiple times for CIA?
Nope its got long lasting immunity