in a cushings animal, concurrent DM is easy to confirm by hyperglycemia, fructosamine, glucouria; in a diabetic, it is difficult to confirm cushings because DM causes chronic stress and will result in false positive ACTH stim tests
Hypersomatotropism occurs in cats with __________ and in dogs with __(2)__.
acidophil adenoma; mammary gland tumors or increased progesterone (diestrus)
What are the effects of excessive GH? (5)
decreased insulin sensitivity, increased protein synthesis, increased bone growth, increased lipolysis, increased IGF-1 production
GH _________ IGF-1 production; insulin has __________ effects on IGF-1 production.
stimulates; permissive (ie. without insulin, IGF-1 will not be produced)
What 2 syndromes are associated with hypersomatotropism?
insulin resistance (and DM), acromegaly
How do hypersomatotropic cats usually present?
PU?PD, polyphagia (acromegaly often not present, or develops in late stages)
What is an important clue that a diabetic cat may also have hypersomatotropism?
lack of weight loss in a diabetic cat that is otherwise uncontrolled
What are common clinical signs of hypersomatotropism? (7)
PU/PD, polyphagia, weight gain, renomegaly, hepatomegaly, systolic murmur, plantigrade stance
What are clinical signs in late stages of hypersomatotropism? (4)