Hardy-Weinberg Principle

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1. Why do we need models
• • Simplicity in a complex world
• • Conceptual vs. Mathematical
• • Models allow us to:
• – Define important parameters
• – Construct testable hypotheses
• – Generalize results
• – Predict the future
2. The Hardy-Weinberg Principle
• • A model to estimate genetic diversity of a
• population from a subsample
• – Based on Mendelian segregation and
• probabilities
3. HW assumptions
• 1. Random mating:
• a. Locus specific (e.g. MC1R locus in geese)
• 2. No mutation:
• a. Mutation is a long-term process (>100s)
• 3. Large population size
• a. Minimal drift
• 4. No selection
• 5. No immigration/no emigration
• 6. Diploids, sexual reproduction, nonoverlapping
• generations, equal allele
• frequencies among sexes
4. Probability Theory in Genetics
• • The PROBABILITY (P) of an event is the # of times the event will occur
• (a) divided by the total # of possible events (n)
• • What is the probability (P) of sampling a bull trout with haplotype A
• from this population?
5. Probability Theory in Genetics
• • The Multiplicative (Product) rule: if events A and B are independent,
• then the probability that they both occur is:
• P(A and B) = P(A) x P(B)
6. The Sum rule
• : the probability of 2 or more mutually exclusive events
• occurring is equal to the sum of their individual probabilities:
• P(A or B) = P(A) + P(B)
7. HWP
• p2 + 2pq + q2 = 1
• p + q = 1
 Author: doncheto ID: 307809 Card Set: Hardy-Weinberg Principle Updated: 2015-09-14 18:01:43 Tags: Hardy Weinberg Principle genetics Folders: Description: marine pop gen Show Answers: