Hardy-Weinberg Principle

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Author:
doncheto
ID:
307809
Filename:
Hardy-Weinberg Principle
Updated:
2015-09-14 14:01:43
Tags:
Hardy Weinberg Principle genetics
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Description:
marine pop gen
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  1. Why do we need models
    • • Simplicity in a complex world
    • • Conceptual vs. Mathematical
    • • Models allow us to:
    • – Define important parameters
    • – Construct testable hypotheses
    • – Generalize results
    • – Predict the future
  2. The Hardy-Weinberg Principle
    • • A model to estimate genetic diversity of a
    • population from a subsample
    • – Based on Mendelian segregation and
    • probabilities
  3. HW assumptions
    • 1. Random mating:
    • a. Locus specific (e.g. MC1R locus in geese)
    • 2. No mutation:
    • a. Mutation is a long-term process (>100s)
    • 3. Large population size
    • a. Minimal drift 
    • 4. No selection
    • 5. No immigration/no emigration
    • 6. Diploids, sexual reproduction, nonoverlapping
    • generations, equal allele
    • frequencies among sexes
  4. Probability Theory in Genetics
    • • The PROBABILITY (P) of an event is the # of times the event will occur
    • (a) divided by the total # of possible events (n)
    • • What is the probability (P) of sampling a bull trout with haplotype A
    • from this population?
  5. Probability Theory in Genetics
    • • The Multiplicative (Product) rule: if events A and B are independent,
    • then the probability that they both occur is:
    • P(A and B) = P(A) x P(B)
  6. The Sum rule
    • : the probability of 2 or more mutually exclusive events
    • occurring is equal to the sum of their individual probabilities:
    • P(A or B) = P(A) + P(B)
  7. HWP
    • p2 + 2pq + q2 = 1
    • p + q = 1

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