Biochemical Markers PP
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What are biochemical markers?
A substance that is detected in the urine, blood or other body fluids or tissues that may serve as a sign of a disease or other abnormality.
What is going to be the first two things a doctor will order when a patient comes in with chest pain?
- 1.) An EKG.
- 2.) Labs to test the biochemical cardiac protein markers.
What are the 5 things that make labs for biochemical protein markers great?
- 1.) highly concentration in myocardium.
- 2.) can be myocardium specific
- 3.) Released early in injury
- 4.) Proportionate to injury
- 5.) Non expensive testing
What are the 3 biochemical protein markers?
- 1.) Myoglobin
- 2.) CKMB
- 3.) Troponins
What is an "NSTEMI"?
a non-ST elevated MI
The EKG is normal and is not elevated like it usually is in presence of heart attack.
How long do doctors usually wait after onset of initial symptoms to test for biochemical markers?
Usually 2 hours
- Myoglobin, Troponins increase after 2 hours.
- CKMB increase after 1 hour.
What is the amino acid that can be tested for with the biochemical markers?
B-type Natriuretic Peptide (BNP)
When is B-type Natriuretic Peptide (BNP) usually increased in the blood?
Is excreted when the ventricles are stressed from having to up the workload for damaged ventricles.
What can B-type Natriuretic Peptide be an indicator of?
What happens to the walls of the heart muscle after a heart attack?
the walls get thinner.
The walls are damaged so don't work which causes them to get weaker = smaller.
Unworked muscles are smaller.
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