PHRD7095 PTX7 Lecture 1 - Immunology

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  1. process of innate immunity
    • 1. engulf
    • 2. eliminate
    • 3. induce inflammation
    • 4. call/activate adaptive immune system
  2. adaptive immune cells (2)
    • T lymphocytes
    • B lymphocytes
  3. Fas-FasL induces what cellular process?
  4. T cells are restricted to what type of recognition?
    antigen presented to them on the surface of a genetically identical cell
  5. which cells contain MHC Class II molecules?
    • B cells
    • APC's
    • macrophages
  6. which cells contain MHC Class I molecules
    all nucleated cells
  7. which cells interact with MHC Class II molecules?
    CD4+ Th1 and Th2 cells
  8. which cells interact with MHC Class I molecules?
    CD8+ CTL cells
  9. 3 requirements for a successful T cell
    • not recognize self
    • not recognize free antigen
    • recognize antigenic peptide plus self MHC
  10. process of central tolerance
    • 1. negative selection
    • 2. rescue from programmed cell death
    • 3. lineage determination
  11. interaction of an APC with CTLA4 causes what cellular process?
  12. donor APCs migrate to a local lymph node and stimulate alloreactive recipient T cells
    direct recognition leading to allograft rejection
  13. recipient APCs process and present peptides derived from the graft
    indirect recognition leading to allograft rejection
  14. sites of action of immunosuppressive drugs (4)
    • 1. antigen recognition
    • 2. production of pro-inflammatory cytokines
    • 3. IL-2 production
    • 4. T-cell production & differentiation
  15. site of Rh (D) immune globulin immunosuppression
    antigen recognition by APC
  16. site of corticosteroid immunosuppression
    production of pro-inflammatory cytokines by APC
  17. site of OKT3 immunosuppression
    binds CD3 on T cell to prevent activation
  18. site of cyclosporine, tacrolimus, and sirolimus immunosuppression
    inside T cell - prevents activation
  19. site of azathioprine & mycophenolate mofetil immunosuppression
    T & B cell proliferation/differentiation
  20. autoimmunity is unwanted immune responses against self-tissue antigens that cause _____.
    chronic inflammatory injury
  21. examples of organ specific autoimmunity
    • insulin dependent diabetes mellitus
    • multiple sclerosis
  22. examples of non-organ specific autoimmunity
    • SLE
    • RA
  23. common features of autoimmune diseases
    • sx vary significantly
    • increased susceptibility of the female sex
    • disease overlap: individuals have symptoms of multiple systemic diseases
  24. chronic, systemic, inflammatory disease that primarily affects the synovial membranes of multiple joints in the body
    rheumatoid arthritis
  25. pathogenesis of RA
    • 1. T cell activation by unknown Ag's
    • 2. initiation of inflammatory response (cytokine production, synovil inflammation)
    • 3. joint swelling, articular OA, articular distortion, bone erosion
  26. possible mechanisms of RA (2)
    • "T cell centric" theory
    • Macrophage model
  27. supporting evidence for T cell centric theory as cause of RA (2)
    • known association of RA w/ MHC II antigens
    • large number of CD4+ T cells in the RA synovium
  28. supporting evidence for the macrophage model as cause of RA (2)
    • relative absence of activated T cell phenotypes in chronic RA
    • preponderance of activated macrophages & fibroblasts
  29. 2 potential exogenous/mimicry peptide antigens causing RA
    • Epstein-Barr protein
    • heat shock protein
  30. 2 potential endogenous peptide antigens causing RA
    • collagen type II
    • Rheumatoid factor
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PHRD7095 PTX7 Lecture 1 - Immunology
2015-09-24 21:10:22

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