GU Patho Exam 1 (3)
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Cells that are part of the monomuclear phagocytic system.
- Monocytes (macrophages)
- Osteoclasts (mult macrophages fused)
- Dendritic Cells (not in blood)
Macrophages of liver, brain, and lungs.
- Liver = Kupffer
- Brain = microglia
- Lungs = Dust cell
_____ and _____ use non-host epitopes.
How long does the adaptive response take?
about 4 days
Job of cytokines released by macrophages.
trigger nearest entohelial cells to stop rolling neutrophils and attract them to the site
What is a LPS?
Lipopolysaccharide receptor on surface of bacteria
Three types of non-host epitopes
- LPS receptor
- Manose receptor
- Glucan receptor
NK-cells check what?
- every cell for MHC1
- if MHC1 is altered or missing, NK kills it
What is arachidonic acid?
polyunsaturated omega-6 fatty acid
What is EPA?
- Eicosapentaenoic Acid
- polyunsaturated omega-3 fatty acid
How do mast cells cut fatty acids out of the middle of a glycerol?
with phospholipase a2
What produces prostaglandins or 5-lyoxygenase?
Function of leukotrienes?
cause tightening of airway muscles and the production of excess mucus and fluid
What is TRANSudate?
fluid on outside of capillaries (interstitial) that does NOT contain proteins
What is Exudate?
fluid on outside of capillaries (interstitial) that DOES contain proteins
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